Component

Plasma glucose concentration

Plasma glucose concentration. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Wild-type mice fed thiamine-deficient diet for 10 days had higher plasma glucose, hepatic glucose and hepatic glycogen.

    Thiamine (vitamin B1) → Plasma glucose concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    curation_topic
    thiamine · Thiamine (vitamin B1)
    experimental_condition
    5 mg/kg control diet 0 mg/kg added thiamine diet · Thiamine (vitamin B1) Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "0 mg/kg added thiamine diet", "comparator": "5 mg/kg control diet", "endpoint": "Plasma glucose", "effect_direction": "increase", "combination": "single", "conditions": [{"entity_slug": "thiamine", "state": "0 mg/kg added thiamine diet"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Mouse dietary experiment, figure 5; 16-hour fast before sampling; n=4 per genotype/treatment
    limitations
    A separate dietary arm of the OCT1 paper; not a berberine exposure experiment or direct proof of human diabetes causation.
    primary_references
    OCT1 cardiometabolic study 2018; DOI:10.1371/journal.pbio.2002907; PMID:29659562; https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002907
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Diabetes cascade: targeted primary-source supplement · lines 36–36

    See claim-local references; curated paraphrases reviewed 2026-09-20. · supports · Mouse dietary experiment, figure 5; 16-hour fast before sampling; n=4 per genotype/treatment · source_derived_draft · unverified_draft

    Wild-type mice fed thiamine-deficient diet for 10 days had higher plasma glucose, hepatic glucose and hepatic glycogen. Model: Mouse dietary experiment, figure 5; 16-hour fast before sampling; n=4 per genotype/treatment. Limits: A separate dietary arm of the OCT1 paper; not a berberine exposure experiment or direct proof of human diabetes causation. Primary reference: OCT1 cardiometabolic study 2018; DOI:10.1371/journal.pbio.2002907; PMID:29659562; https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002907
    Complete structured claim and evidence

  2. The extract groups showed reduced fasting plasma glucose from baseline; treatment assignment was a significant predictor of change in the reported regression.

    C. zeylanicum extract in the 2025 diabetes trial → Plasma glucose concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/41412108.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9", "start_char": 0, "end_char": 1887, "text_sha256": "41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9"}
    experimental_model
    Three-arm randomized placebo-controlled diabetes trial
    exposure
    210 randomized; 186 completed four months; 250 or 500 mg extract groups
    limitations
    The accessible abstract reports within-baseline changes and regression significance, without a full numeric between-group effect estimate. Do not turn these into a precise placebo-adjusted magnitude.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    The study reported improved fasting plasma glucose, but the accessible abstract does not provide the full treatment-versus-placebo effect size.
    primary_references
    [ceylon-p41412108] Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/41412108/ DOI: 10.1016/j.dsx.2025.103357
    tissue_or_cell_type
    Type 2 diabetes cohort

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1169–1180

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-arm randomized placebo-controlled diabetes trial · source_derived_draft · unverified_draft

    ### ceylon-diabetes-fpg The extract groups showed reduced fasting plasma glucose from baseline; treatment assignment was a significant predictor of change in the reported regression. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study reported improved fasting plasma glucose, but the accessible abstract does not provide the full treatment-versus-placebo effect size. organism: Human tissue_or_cell_type: Type 2 diabetes cohort experimental_model: Three-arm randomized placebo-controlled diabetes trial limitations: The accessible abstract reports within-baseline changes and regression significance, without a full numeric between-group effect estimate. Do not turn these into a precise placebo-adjusted magnitude. exposure: 210 randomized; 186 completed four months; 250 or 500 mg extract groups evidence_span: {"source_cache": "artifacts/ceylon-research/41412108.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9", "start_char": 0, "end_char": 1887, "text_sha256": "41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9"} [ceylon-p41412108] Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/41412108/ DOI: 10.1016/j.dsx.2025.103357
    Complete structured claim and evidence

  3. Boron supplementation returned elevated plasma glucose concentrations in vitamin-D3-inadequate chicks toward those in vitamin-D3-adequate chicks.

    Boric acid / orthoboric acid / B(OH)3 → Plasma glucose concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/8140930.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc", "start_char": 0, "end_char": 1621, "text_sha256": "6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc"}
    experimental_model
    Factorial boron/vitamin-D3 feeding experiment in chicks
    exposure
    26 days; basal boron ≤0.18 mg/kg with 0 or 1.4 mg/kg orthoboric acid supplement; vitamin D3 3.13 or 15.6 µg/kg
    limitations
    Animal developmental experiment. It did not demonstrate direct CYP24A1 inhibition or that boron replaces vitamin D in humans.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Day-old cockerel chicks
    plain_language
    Some metabolic changes from inadequate vitamin D improved in this chick experiment.
    primary_references
    [boron-p8140930] Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. (1994). https://pubmed.ncbi.nlm.nih.gov/8140930/ DOI: 10.1002/jbmr.5650090206
    tissue_or_cell_type
    Plasma metabolism and growth plates
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 846–857

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Factorial boron/vitamin-D3 feeding experiment in chicks · source_derived_draft · unverified_draft

    ### boron-chick-glucose Boron supplementation returned elevated plasma glucose concentrations in vitamin-D3-inadequate chicks toward those in vitamin-D3-adequate chicks. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Some metabolic changes from inadequate vitamin D improved in this chick experiment. organism: Day-old cockerel chicks tissue_or_cell_type: Plasma metabolism and growth plates experimental_model: Factorial boron/vitamin-D3 feeding experiment in chicks limitations: Animal developmental experiment. It did not demonstrate direct CYP24A1 inhibition or that boron replaces vitamin D in humans. exposure: 26 days; basal boron ≤0.18 mg/kg with 0 or 1.4 mg/kg orthoboric acid supplement; vitamin D3 3.13 or 15.6 µg/kg evidence_span: {"source_cache": "artifacts/boron-research/8140930.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc", "start_char": 0, "end_char": 1621, "text_sha256": "6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc"} [boron-p8140930] Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. (1994). https://pubmed.ncbi.nlm.nih.gov/8140930/ DOI: 10.1002/jbmr.5650090206
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards