{"id":"d90ec4b2-5716-52bd-b395-55c301842a85","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:oct1-paper-dietary-thiamine-glucose","predicate":"reported_comparison","statement":"Wild-type mice fed thiamine-deficient diet for 10 days had higher plasma glucose, hepatic glucose and hepatic glycogen.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0d100b50-1b8c-5e9c-9920-2c9235cd2d59","mechanism_event_label":"Wild-type mice fed thiamine-deficient diet for 10 days had higher plasma glucose, hepatic glucose and hepatic glycogen.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"d0c4525a-2faf-5cf1-806a-1a4328eea4cc","slug":"plasma-glucose-concentration","display_name":"Plasma glucose concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0d100b50-1b8c-5e9c-9920-2c9235cd2d59","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:oct1-paper-dietary-thiamine-glucose","event_type":"reported_comparison","label":"Wild-type mice fed thiamine-deficient diet for 10 days had higher plasma glucose, hepatic glucose and hepatic glycogen.","description":"","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"experimental_actor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d0c4525a-2faf-5cf1-806a-1a4328eea4cc","slug":"plasma-glucose-concentration","display_name":"Plasma glucose concentration","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5b7e7ec2-0310-53bc-b1dd-ad3bac9803cf","slug":"mouse-slc22a1","display_name":"Mouse organic cation transporter 1 / Oct1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"curation_topic","value_text":"thiamine","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"0 mg/kg added thiamine diet","comparator":"5 mg/kg control diet","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"0 mg/kg added thiamine diet\", \"comparator\": \"5 mg/kg control diet\", \"endpoint\": \"Plasma glucose\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": [{\"entity_slug\": \"thiamine\", \"state\": \"0 mg/kg added thiamine diet\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Mouse dietary experiment, figure 5; 16-hour fast before sampling; n=4 per genotype/treatment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A separate dietary arm of the OCT1 paper; not a berberine exposure experiment or direct proof of human diabetes causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"OCT1 cardiometabolic study 2018; DOI:10.1371/journal.pbio.2002907; PMID:29659562; https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002907","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e95d5c8e-1240-5ac8-bce1-743c76801fbb","evidence_kind":"source_excerpt","locator":"Lines 36-36","start_line":36,"end_line":36,"excerpt":"Wild-type mice fed thiamine-deficient diet for 10 days had higher plasma glucose, hepatic glucose and hepatic glycogen. Model: Mouse dietary experiment, figure 5; 16-hour fast before sampling; n=4 per genotype/treatment. Limits: A separate dietary arm of the OCT1 paper; not a berberine exposure experiment or direct proof of human diabetes causation. 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