{"id":"4d0a6420-9351-5311-be60-9f90ae427291","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-diabetes-fpg","predicate":"has_reported_within_group_reduction","statement":"The extract groups showed reduced fasting plasma glucose from baseline; treatment assignment was a significant predictor of change in the reported regression.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"14de7a81-6897-5a41-9378-176c1320d997","mechanism_event_label":"The study reported improved fasting plasma glucose, but the accessible abstract does not provide the full treatment-versus-placebo effect size.","subject":{"id":"e2ff345b-1f36-5b19-bb2e-8add28d96fac","slug":"ceylon-extract-diabetes-rct","display_name":"C. zeylanicum extract in the 2025 diabetes trial","entity_type_key":"chemical_species"},"object":{"id":"d0c4525a-2faf-5cf1-806a-1a4328eea4cc","slug":"plasma-glucose-concentration","display_name":"Plasma glucose concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"14de7a81-6897-5a41-9378-176c1320d997","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-diabetes-fpg-event","event_type":"observed_intervention","label":"The study reported improved fasting plasma glucose, but the accessible abstract does not provide the full treatment-versus-placebo effect size.","description":"The extract groups showed reduced fasting plasma glucose from baseline; treatment assignment was a significant predictor of change in the reported regression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e2ff345b-1f36-5b19-bb2e-8add28d96fac","slug":"ceylon-extract-diabetes-rct","display_name":"C. zeylanicum extract in the 2025 diabetes trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d0c4525a-2faf-5cf1-806a-1a4328eea4cc","slug":"plasma-glucose-concentration","display_name":"Plasma glucose concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/41412108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9\", \"start_char\": 0, \"end_char\": 1887, \"text_sha256\": \"41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-arm randomized placebo-controlled diabetes trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"210 randomized; 186 completed four months; 250 or 500 mg extract groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The accessible abstract reports within-baseline changes and regression significance, without a full numeric between-group effect estimate. Do not turn these into a precise placebo-adjusted magnitude.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study reported improved fasting plasma glucose, but the accessible abstract does not provide the full treatment-versus-placebo effect size.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p41412108] Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/41412108/ DOI: 10.1016/j.dsx.2025.103357","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Type 2 diabetes cohort","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f278f48f-4601-5b2a-a8b5-0cae50523c70","evidence_kind":"source_excerpt","locator":"Lines 1169-1180","start_line":1169,"end_line":1180,"excerpt":"### ceylon-diabetes-fpg\nThe extract groups showed reduced fasting plasma glucose from baseline; treatment assignment was a significant predictor of change in the reported regression.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The study reported improved fasting plasma glucose, but the accessible abstract does not provide the full treatment-versus-placebo effect size.\norganism: Human\ntissue_or_cell_type: Type 2 diabetes cohort\nexperimental_model: Three-arm randomized placebo-controlled diabetes trial\nlimitations: The accessible abstract reports within-baseline changes and regression significance, without a full numeric between-group effect estimate. Do not turn these into a precise placebo-adjusted magnitude.\nexposure: 210 randomized; 186 completed four months; 250 or 500 mg extract groups\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/41412108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9\", \"start_char\": 0, \"end_char\": 1887, \"text_sha256\": \"41424e14da4786345bad52af19c8ccee1a37f445a402edaa855b87ee01d389b9\"}\n[ceylon-p41412108] Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/41412108/ DOI: 10.1016/j.dsx.2025.103357","model_system":"Three-arm randomized placebo-controlled diabetes trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p41412108] Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/41412108/ DOI: 10.1016/j.dsx.2025.103357","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"639b1d8dcff42f2cf1f00a7dc38202289b70213e37c357c375b1f5905d6cf832","revision_id":"9675eb03-ee34-5160-b928-46b6ca9d1ecc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}