Component
Plasma calcifediol concentration
Independent biological entity. Read linked claims for experimental scope and context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Magnesium assignment altered plasma 25(OH)D3 differently by baseline vitamin D: an increase near 30 ng/mL and a decrease at higher baseline concentrations.
Experimental context and source evidence
- cross_nutrient
- Magnesium <-> vitamin D status; baseline-dependent clinical endpoint.
- experimental_model
- Randomized 12-week ancillary analysis, 180 adults.
- exposure
- Personalized Mg supplementation; baseline calcium:magnesium intake ratio at least 2.6. Ratios describe enrollment, not a recommended target.
- limitations
- Only two participants had overt vitamin D deficiency; the trial does not show universal deficiency rescue or identify the responsible enzyme.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Homo sapiens
- plain_language
- The vitamin D response depended on the starting level.
- primary_references
- [mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274
- tissue_or_cell_type
- Human plasma
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1430–1441
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized 12-week ancillary analysis, 180 adults. · source_derived_draft · unverified_draft
### mg-supplement-calcifediol-baseline-dependent Magnesium assignment altered plasma 25(OH)D3 differently by baseline vitamin D: an increase near 30 ng/mL and a decrease at higher baseline concentrations. Condition category: normal nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The vitamin D response depended on the starting level. organism: Homo sapiens tissue_or_cell_type: Human plasma experimental_model: Randomized 12-week ancillary analysis, 180 adults. limitations: Only two participants had overt vitamin D deficiency; the trial does not show universal deficiency rescue or identify the responsible enzyme. cross_nutrient: Magnesium <-> vitamin D status; baseline-dependent clinical endpoint. exposure: Personalized Mg supplementation; baseline calcium:magnesium intake ratio at least 2.6. Ratios describe enrollment, not a recommended target. [mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.