{"id":"93dca2a3-1ef1-5e6a-ae26-5d52c10ac9dc","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-supplement-calcifediol-baseline-dependent","predicate":"changes_in_context","statement":"Magnesium assignment altered plasma 25(OH)D3 differently by baseline vitamin D: an increase near 30 ng/mL and a decrease at higher baseline concentrations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9aa88503-8599-5167-8c63-43a76da8816b","mechanism_event_label":"The vitamin D response depended on the starting level.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"e33ed9b6-44cf-5db7-aa1d-5356a7815acd","slug":"plasma-calcifediol-concentration","display_name":"Plasma calcifediol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9aa88503-8599-5167-8c63-43a76da8816b","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-supplement-calcifediol-baseline-dependent-event","event_type":"observed_intervention","label":"The vitamin D response depended on the starting level.","description":"Magnesium assignment altered plasma 25(OH)D3 differently by baseline vitamin D: an increase near 30 ng/mL and a decrease at higher baseline concentrations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6bd73bd2-1f0a-5caa-ba69-7ce1b75364bb","slug":"calcifediol","display_name":"Calcifediol / 25-hydroxyvitamin D3","entity_type_key":"small_molecule"},"role":"measured_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"dietary_ratio_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e33ed9b6-44cf-5db7-aa1d-5356a7815acd","slug":"plasma-calcifediol-concentration","display_name":"Plasma calcifediol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Magnesium <-> vitamin D status; baseline-dependent clinical endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized 12-week ancillary analysis, 180 adults.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Personalized Mg supplementation; baseline calcium:magnesium intake ratio at least 2.6. Ratios describe enrollment, not a recommended target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Only two participants had overt vitamin D deficiency; the trial does not show universal deficiency rescue or identify the responsible enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The vitamin D response depended on the starting level.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"baf03155-9bf4-5fd3-ad8a-e5d3142e19d6","evidence_kind":"source_excerpt","locator":"Lines 1430-1441","start_line":1430,"end_line":1441,"excerpt":"### mg-supplement-calcifediol-baseline-dependent\nMagnesium assignment altered plasma 25(OH)D3 differently by baseline vitamin D: an increase near 30 ng/mL and a decrease at higher baseline concentrations.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The vitamin D response depended on the starting level.\norganism: Homo sapiens\ntissue_or_cell_type: Human plasma\nexperimental_model: Randomized 12-week ancillary analysis, 180 adults.\nlimitations: Only two participants had overt vitamin D deficiency; the trial does not show universal deficiency rescue or identify the responsible enzyme.\ncross_nutrient: Magnesium <-> vitamin D status; baseline-dependent clinical endpoint.\nexposure: Personalized Mg supplementation; baseline calcium:magnesium intake ratio at least 2.6. Ratios describe enrollment, not a recommended target.\n[mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274","model_system":"Randomized 12-week ancillary analysis, 180 adults.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}