Component

Plasma C-reactive protein concentration

Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. High-sensitivity CRP decreased at the six-hour measurement after boron supplementation in the eight-man study.

    Boron → Plasma C-reactive protein concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/21129941.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157", "start_char": 0, "end_char": 1706, "text_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157"}
    experimental_model
    Sequential placebo-day and supplementation observations in eight men
    exposure
    10 mg boron/day for one week; acute six-hour and day-seven measurements
    limitations
    Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human healthy male volunteers
    plain_language
    One inflammation marker fell over the short observation period.
    primary_references
    [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001
    tissue_or_cell_type
    Circulating CRP assay; sample matrix retained as reported by the indexed abstract

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 1041–1052

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential placebo-day and supplementation observations in eight men · source_derived_draft · unverified_draft

    ### boron-short-study-crp High-sensitivity CRP decreased at the six-hour measurement after boron supplementation in the eight-man study. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: One inflammation marker fell over the short observation period. organism: Human healthy male volunteers tissue_or_cell_type: Circulating CRP assay; sample matrix retained as reported by the indexed abstract experimental_model: Sequential placebo-day and supplementation observations in eight men limitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG. exposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements evidence_span: {"source_cache": "artifacts/boron-research/21129941.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157", "start_char": 0, "end_char": 1706, "text_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157"} [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001
    Complete structured claim and evidence

  2. At 168 hours, the prespecified CRP comparison was nonsignificant (P=0.33).

    L-Ascorbic acid → Plasma C-reactive protein concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo).
    exposure
    IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo.
    limitations
    Marker results do not establish that every inflammatory pathway was unchanged.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    This inflammatory marker did not show the proposed benefit.
    primary_references
    [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825
    tissue_or_cell_type
    Human blood or whole-person endpoints

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1731–1741

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo). · source_derived_draft · unverified_draft

    ### c-citris-crp-null At 168 hours, the prespecified CRP comparison was nonsignificant (P=0.33). Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: This inflammatory marker did not show the proposed benefit. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo). limitations: Marker results do not establish that every inflammatory pathway was unchanged. exposure: IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo. [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards