{"id":"9c1a8545-8ecb-5a2c-a6ae-20a8df20e4a3","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-crp","predicate":"reduces","statement":"High-sensitivity CRP decreased at the six-hour measurement after boron supplementation in the eight-man study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"36fd8ccb-625c-5407-92e1-0c1be627c4e2","mechanism_event_label":"One inflammation marker fell over the short observation period.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"f7efb182-0652-552b-b93e-5adb2d08e6c1","slug":"plasma-c-reactive-protein-concentration","display_name":"Plasma C-reactive protein concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"36fd8ccb-625c-5407-92e1-0c1be627c4e2","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-crp-event","event_type":"observed_intervention","label":"One inflammation marker fell over the short observation period.","description":"High-sensitivity CRP decreased at the six-hour measurement after boron supplementation in the eight-man study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f7efb182-0652-552b-b93e-5adb2d08e6c1","slug":"plasma-c-reactive-protein-concentration","display_name":"Plasma C-reactive protein concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential placebo-day and supplementation observations in eight men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10 mg boron/day for one week; acute six-hour and day-seven measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human healthy male volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One inflammation marker fell over the short observation period.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating CRP assay; sample matrix retained as reported by the indexed abstract","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f9a33428-9e58-58b7-9ae3-67819a95fb0a","evidence_kind":"source_excerpt","locator":"Lines 1041-1052","start_line":1041,"end_line":1052,"excerpt":"### boron-short-study-crp\nHigh-sensitivity CRP decreased at the six-hour measurement after boron supplementation in the eight-man study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One inflammation marker fell over the short observation period.\norganism: Human healthy male volunteers\ntissue_or_cell_type: Circulating CRP assay; sample matrix retained as reported by the indexed abstract\nexperimental_model: Sequential placebo-day and supplementation observations in eight men\nlimitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.\nexposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements\nevidence_span: {\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}\n[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","model_system":"Sequential placebo-day and supplementation observations in eight men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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