Component

Plasma ascorbate concentration

Plasma ascorbate concentration Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. At the same measured 1.25-g dose, mean peak plasma vitamin C was 134.8 ± 20.6 micromol/L orally versus 885 ± 201.2 micromol/L intravenously.

    L-Ascorbic acid → Plasma ascorbate concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Seventeen healthy hospitalized volunteers; measured dose/concentration experiments plus pharmacokinetic modeling.
    exposure
    Measured oral/IV doses 0.015–1.25 g; modeled doses 1–100 g. Larger modeled exposures were not validated in cancer patients.
    limitations
    Healthy-volunteer pharmacokinetics, not evidence of cancer efficacy.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    Bypassing the gut produced a much larger blood peak for the same administered amount.
    primary_references
    [c-padayatty2004] Vitamin C pharmacokinetics: implications for oral and intravenous use (2004). https://pubmed.ncbi.nlm.nih.gov/15068981/ DOI: 10.7326/0003-4819-140-7-200404060-00010
    tissue_or_cell_type
    Human blood or whole-person endpoints

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1469–1479

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seventeen healthy hospitalized volunteers; measured dose/concentration experiments plus pharmacokinetic modeling. · source_derived_draft · unverified_draft

    ### c-oral-iv-measured-peaks At the same measured 1.25-g dose, mean peak plasma vitamin C was 134.8 ± 20.6 micromol/L orally versus 885 ± 201.2 micromol/L intravenously. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Bypassing the gut produced a much larger blood peak for the same administered amount. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Seventeen healthy hospitalized volunteers; measured dose/concentration experiments plus pharmacokinetic modeling. limitations: Healthy-volunteer pharmacokinetics, not evidence of cancer efficacy. exposure: Measured oral/IV doses 0.015–1.25 g; modeled doses 1–100 g. Larger modeled exposures were not validated in cancer patients. [c-padayatty2004] Vitamin C pharmacokinetics: implications for oral and intravenous use (2004). https://pubmed.ncbi.nlm.nih.gov/15068981/ DOI: 10.7326/0003-4819-140-7-200404060-00010
    Complete structured claim and evidence

  2. The model predicted peaks of 220 micromol/L for oral 3 g every four hours and 13400 micromol/L for 50 g IV.

    L-Ascorbic acid → Plasma ascorbate concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Seventeen healthy hospitalized volunteers; measured dose/concentration experiments plus pharmacokinetic modeling.
    exposure
    Measured oral/IV doses 0.015–1.25 g; modeled doses 1–100 g. Larger modeled exposures were not validated in cancer patients.
    limitations
    These high-dose values were calculated, not measured in this study; no patient recommendation or proof of benefit.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    The model illustrates why oral and intravenous experiments cannot be treated as equivalent exposures.
    primary_references
    [c-padayatty2004] Vitamin C pharmacokinetics: implications for oral and intravenous use (2004). https://pubmed.ncbi.nlm.nih.gov/15068981/ DOI: 10.7326/0003-4819-140-7-200404060-00010
    tissue_or_cell_type
    Human blood or whole-person endpoints

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1481–1491

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seventeen healthy hospitalized volunteers; measured dose/concentration experiments plus pharmacokinetic modeling. · source_derived_draft · unverified_draft

    ### c-oral-iv-modeled-peaks The model predicted peaks of 220 micromol/L for oral 3 g every four hours and 13400 micromol/L for 50 g IV. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The model illustrates why oral and intravenous experiments cannot be treated as equivalent exposures. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Seventeen healthy hospitalized volunteers; measured dose/concentration experiments plus pharmacokinetic modeling. limitations: These high-dose values were calculated, not measured in this study; no patient recommendation or proof of benefit. exposure: Measured oral/IV doses 0.015–1.25 g; modeled doses 1–100 g. Larger modeled exposures were not validated in cancer patients. [c-padayatty2004] Vitamin C pharmacokinetics: implications for oral and intravenous use (2004). https://pubmed.ncbi.nlm.nih.gov/15068981/ DOI: 10.7326/0003-4819-140-7-200404060-00010
    Complete structured claim and evidence

  3. Steady-state plasma vitamin C followed a sigmoid dose-response: steepest at 30–100 mg/day, beyond the sigmoid region at 200 mg/day, with complete saturation reported at 1000 mg/day in this cohort.

    L-Ascorbic acid → Plasma ascorbate concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Seven healthy volunteers hospitalized for 4–6 months in a controlled depletion/repletion study.
    exposure
    Diet below 5 mg vitamin C/day, followed by seven daily doses spanning 30–2500 mg; separate single-dose bioavailability assessments.
    limitations
    Small controlled cohort; saturation is assay- and endpoint-specific. Historical authors’ RDA and safety proposals are not presented as current universal guidance.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    Taking more changed the blood level much less once the curve flattened.
    primary_references
    [c-levine1996] Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance (1996). https://pubmed.ncbi.nlm.nih.gov/8623000/ DOI: 10.1073/pnas.93.8.3704
    tissue_or_cell_type
    Human blood or whole-person endpoints

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1397–1407

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven healthy volunteers hospitalized for 4–6 months in a controlled depletion/repletion study. · source_derived_draft · unverified_draft

    ### c-plasma-dose-sigmoid Steady-state plasma vitamin C followed a sigmoid dose-response: steepest at 30–100 mg/day, beyond the sigmoid region at 200 mg/day, with complete saturation reported at 1000 mg/day in this cohort. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Taking more changed the blood level much less once the curve flattened. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Seven healthy volunteers hospitalized for 4–6 months in a controlled depletion/repletion study. limitations: Small controlled cohort; saturation is assay- and endpoint-specific. Historical authors’ RDA and safety proposals are not presented as current universal guidance. exposure: Diet below 5 mg vitamin C/day, followed by seven daily doses spanning 30–2500 mg; separate single-dose bioavailability assessments. [c-levine1996] Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance (1996). https://pubmed.ncbi.nlm.nih.gov/8623000/ DOI: 10.1073/pnas.93.8.3704
    Complete structured claim and evidence

  4. The publisher summary reports near disappearance of ascorbic acid from blood and urine, with erratic low-level readings attributed to an interfering substance.

    Vitamin C → Plasma ascorbate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    experimental_model
    Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.
    exposure
    Diet devoid of vitamin C but adequate in other essential nutrients.
    limitations
    Blood and urine findings are not measurements of every tissue pool.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    Very low readings accompanied scurvy, but the historical assay became unreliable near depletion.
    primary_references
    [c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535
    tissue_or_cell_type
    Human blood or whole-person endpoints
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1505–1515

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy. · source_derived_draft · unverified_draft

    ### c-scurvy-circulating-depletion The publisher summary reports near disappearance of ascorbic acid from blood and urine, with erratic low-level readings attributed to an interfering substance. Condition category: nutrient_deficiency nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Very low readings accompanied scurvy, but the historical assay became unreliable near depletion. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy. limitations: Blood and urine findings are not measurements of every tissue pool. exposure: Diet devoid of vitamin C but adequate in other essential nutrients. [c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535
    Complete structured claim and evidence

  5. In the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine.

    L-Ascorbic acid → Plasma ascorbate concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study.
    exposure
    Vitamin C 30–2500 mg/day at sequential steady states. Participant count is not extracted from the inspected abstract.
    limitations
    Study differences do not establish a fixed sex-specific requirement; these are historical experimental endpoints.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    The measured pools reached a plateau in this separate cohort.
    primary_references
    [c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198
    tissue_or_cell_type
    Human blood or whole-person endpoints

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1445–1455

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study. · source_derived_draft · unverified_draft

    ### c-women-plasma-saturation In the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured pools reached a plateau in this separate cohort. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study. limitations: Study differences do not establish a fixed sex-specific requirement; these are historical experimental endpoints. exposure: Vitamin C 30–2500 mg/day at sequential steady states. Participant count is not extracted from the inspected abstract. [c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198
    Complete structured claim and evidence

  6. Plasma ascorbate was approximately 50–70% lower in Slc23a1-null mice than wild-type mice.

    Mouse Slc23a1 gene → Plasma ascorbate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Slc23a1 knockout mice and wild-type controls
    exposure
    Slc23a1 knockout versus wild type
    limitations
    Mouse concentration phenotype; do not use as a human deficiency threshold.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Mus musculus
    plain_language
    Renal vitamin C wasting lowered circulating vitamin C in these mice.
    primary_references
    [corpe2010] Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191
    tissue_or_cell_type
    Plasma
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 156–167

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Slc23a1 knockout mice and wild-type controls · source_derived_draft · unverified_draft

    ### vc-transport-svct1-plasma Plasma ascorbate was approximately 50–70% lower in Slc23a1-null mice than wild-type mice. Condition category: machinery_impairment nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Renal vitamin C wasting lowered circulating vitamin C in these mice. organism: Mus musculus tissue_or_cell_type: Plasma experimental_model: Slc23a1 knockout mice and wild-type controls limitations: Mouse concentration phenotype; do not use as a human deficiency threshold. exposure: Slc23a1 knockout versus wild type cross_nutrient: false [corpe2010] Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20200446/ DOI: 10.1172/jci39191
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

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