{"id":"c765fc62-fd7d-576c-b0f6-cd8c3f0a1e5e","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-women-plasma-saturation","predicate":"oral_dose_saturates_plasma_and_cell_pools","statement":"In the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a05755b-c05e-5496-8219-fe238d4a2862","mechanism_event_label":"The measured pools reached a plateau in this separate cohort.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"82e3e6b4-3f0f-5fee-b37f-d076185d7b72","slug":"plasma-ascorbate-concentration","display_name":"Plasma ascorbate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8a05755b-c05e-5496-8219-fe238d4a2862","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-women-plasma-saturation-event","event_type":"observed_intervention","label":"The measured pools reached a plateau in this separate cohort.","description":"In the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fe9e9a3b-8223-5ebf-98ce-e14979bd6d78","slug":"circulating-leukocyte-ascorbate-concentration","display_name":"Circulating leukocyte ascorbate concentration","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a302e504-ad40-51a4-8ccd-7df9d90e317f","slug":"urinary-ascorbate-excretion","display_name":"Urinary ascorbate excretion","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"82e3e6b4-3f0f-5fee-b37f-d076185d7b72","slug":"plasma-ascorbate-concentration","display_name":"Plasma ascorbate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Vitamin C 30–2500 mg/day at sequential steady states. Participant count is not extracted from the inspected abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study differences do not establish a fixed sex-specific requirement; these are historical experimental endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The measured pools reached a plateau in this separate cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"240ff0b4-d7cf-54d5-a5fc-3e4047fb8125","evidence_kind":"source_excerpt","locator":"Lines 1445-1455","start_line":1445,"end_line":1455,"excerpt":"### c-women-plasma-saturation\nIn the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured pools reached a plateau in this separate cohort.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study.\nlimitations: Study differences do not establish a fixed sex-specific requirement; these are historical experimental endpoints.\nexposure: Vitamin C 30–2500 mg/day at sequential steady states. Participant count is not extracted from the inspected abstract.\n[c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198","model_system":"Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}