{"id":"3bf3ccc4-7001-5944-bbc2-3ad25048521c","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-scurvy-circulating-depletion","predicate":"dietary_depletion_lowers_circulating_ascorbate","statement":"The publisher summary reports near disappearance of ascorbic acid from blood and urine, with erratic low-level readings attributed to an interfering substance.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b186774c-9b2c-597d-aacc-72f94c503fe4","mechanism_event_label":"Very low readings accompanied scurvy, but the historical assay became unreliable near depletion.","subject":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"object":{"id":"82e3e6b4-3f0f-5fee-b37f-d076185d7b72","slug":"plasma-ascorbate-concentration","display_name":"Plasma ascorbate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b186774c-9b2c-597d-aacc-72f94c503fe4","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-scurvy-circulating-depletion-event","event_type":"observed_intervention","label":"Very low readings accompanied scurvy, but the historical assay became unreliable near depletion.","description":"The publisher summary reports near disappearance of ascorbic acid from blood and urine, with erratic low-level readings attributed to an interfering substance.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"82e3e6b4-3f0f-5fee-b37f-d076185d7b72","slug":"plasma-ascorbate-concentration","display_name":"Plasma ascorbate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diet devoid of vitamin C but adequate in other essential nutrients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Blood and urine findings are not measurements of every tissue pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Very low readings accompanied scurvy, but the historical assay became unreliable near depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e7b444cd-a384-58a0-850b-4557a812a903","evidence_kind":"source_excerpt","locator":"Lines 1505-1515","start_line":1505,"end_line":1515,"excerpt":"### c-scurvy-circulating-depletion\nThe publisher summary reports near disappearance of ascorbic acid from blood and urine, with erratic low-level readings attributed to an interfering substance.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Very low readings accompanied scurvy, but the historical assay became unreliable near depletion.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.\nlimitations: Blood and urine findings are not measurements of every tissue pool.\nexposure: Diet devoid of vitamin C but adequate in other essential nutrients.\n[c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","model_system":"Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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