Component
Histone propionylation in PDA cell models
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In the preprint, propionate rescued propionyl-CoA and selected histone propionylation after combined isoleucine/valine deprivation, but did not restore proliferation.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary preprint full text; not peer reviewed
- experimental_model
- Mouse KPC and human PDA cell assays; combined Ile/Val removal, twenty-four hours.
- limitations
- Preprint; deprivation of two amino acids cannot be attributed exclusively to one.
- nutrient_topic
- L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Isoleucine
- plain_language
- Restoring one carbon product did not replace essential amino-acid supply.
- primary_references
- A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40568091/ · DOI 10.1101/2025.04.23.650241
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19) · lines 482–488
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse KPC and human PDA cell assays; combined Ile/Val removal, twenty-four hours. · source_derived_draft · unverified_draft
## isoleucine-pancreatic-preprint-rescue Restoring one carbon product did not replace essential amino-acid supply. In the preprint, propionate rescued propionyl-CoA and selected histone propionylation after combined isoleucine/valine deprivation, but did not restore proliferation. Model: Mouse KPC and human PDA cell assays; combined Ile/Val removal, twenty-four hours. Limitations: Preprint; deprivation of two amino acids cannot be attributed exclusively to one. Evidence access: Primary preprint full text; not peer reviewed A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40568091/ · DOI 10.1101/2025.04.23.650241
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.