{"id":"32da26af-abd3-522e-abcf-80d036278367","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-pancreatic-preprint-rescue","predicate":"rescues_tested","statement":"In the preprint, propionate rescued propionyl-CoA and selected histone propionylation after combined isoleucine/valine deprivation, but did not restore proliferation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4121faf0-507b-577a-b2bf-79b01a988876","mechanism_event_label":"Restoring one carbon product did not replace essential amino-acid supply.","subject":{"id":"f3eec97e-b0aa-59a2-9947-b205a7efdb10","slug":"propionate","display_name":"Propionate","entity_type_key":"small_molecule"},"object":{"id":"12ecbd75-9663-5697-9635-6790b2ff340f","slug":"pda-histone-propionylation","display_name":"Histone propionylation in PDA cell models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4121faf0-507b-577a-b2bf-79b01a988876","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-pancreatic-preprint-rescue-event","event_type":"observed_relationship","label":"Restoring one carbon product did not replace essential amino-acid supply.","description":"In the preprint, propionate rescued propionyl-CoA and selected histone propionylation after combined isoleucine/valine deprivation, but did not restore proliferation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3eec97e-b0aa-59a2-9947-b205a7efdb10","slug":"propionate","display_name":"Propionate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"12ecbd75-9663-5697-9635-6790b2ff340f","slug":"pda-histone-propionylation","display_name":"Histone propionylation in PDA cell models","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c85b327e-f132-5d9a-8e4b-c2976fcc0373","slug":"isoleucine","display_name":"L-Isoleucine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ae40617e-3df7-5d48-8dd2-f16a0d3a8a25","slug":"valine","display_name":"L-Valine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"69ac0570-94d8-59d8-85ef-7f67cf302d16","slug":"propionyl-coa","display_name":"Propionyl-CoA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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