Component

Human poly(rC)-binding protein 1 / PCBP1

Human poly(rC)-binding protein 1 / PCBP1. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. PCBP1 depletion inhibited ferritin iron loading and increased cytosolic iron pools in human cells.

    Human poly(rC)-binding protein 1 / PCBP1 → Cellular labile iron pool source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/iron-research/18511687.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68", "start_char": 0, "end_char": 703, "text_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68"}
    experimental_model
    Yeast expression, in-vitro binding/loading and human-cell depletion
    exposure
    PCBP1 expression and depletion
    limitations
    Chaperone-mediated distribution is distinct from total cellular iron.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Human PCBP1 and ferritin in yeast and human cells
    plain_language
    Less iron in storage can coexist with more potentially reactive iron outside the store.
    primary_references
    [iron-p18511687] A cytosolic iron chaperone that delivers iron to ferritin. (2008). https://pubmed.ncbi.nlm.nih.gov/18511687/ DOI: 10.1126/science.1157643
    tissue_or_cell_type
    Cytosol
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 602–613

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Yeast expression, in-vitro binding/loading and human-cell depletion · source_derived_draft · unverified_draft

    ### iron-pcbp-depletion PCBP1 depletion inhibited ferritin iron loading and increased cytosolic iron pools in human cells. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less iron in storage can coexist with more potentially reactive iron outside the store. organism: Human PCBP1 and ferritin in yeast and human cells tissue_or_cell_type: Cytosol experimental_model: Yeast expression, in-vitro binding/loading and human-cell depletion limitations: Chaperone-mediated distribution is distinct from total cellular iron. exposure: PCBP1 expression and depletion evidence_span: {"source_cache": "artifacts/iron-research/18511687.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68", "start_char": 0, "end_char": 703, "text_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68"} [iron-p18511687] A cytosolic iron chaperone that delivers iron to ferritin. (2008). https://pubmed.ncbi.nlm.nih.gov/18511687/ DOI: 10.1126/science.1157643
    Complete structured claim and evidence

  2. PCBP1 bound iron and ferritin and facilitated iron loading into ferritin in vitro and in cellular systems.

    Human poly(rC)-binding protein 1 / PCBP1 → Iron loading into cellular ferritin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/18511687.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68", "start_char": 0, "end_char": 703, "text_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68"}
    experimental_model
    Yeast expression, in-vitro binding/loading and human-cell depletion
    exposure
    PCBP1 expression and depletion
    limitations
    Chaperone-mediated distribution is distinct from total cellular iron.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Human PCBP1 and ferritin in yeast and human cells
    plain_language
    Iron has a delivery protein for safe storage, rather than simply drifting into every target.
    primary_references
    [iron-p18511687] A cytosolic iron chaperone that delivers iron to ferritin. (2008). https://pubmed.ncbi.nlm.nih.gov/18511687/ DOI: 10.1126/science.1157643
    tissue_or_cell_type
    Cytosol

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 589–600

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Yeast expression, in-vitro binding/loading and human-cell depletion · source_derived_draft · unverified_draft

    ### iron-pcbp-loads-ferritin PCBP1 bound iron and ferritin and facilitated iron loading into ferritin in vitro and in cellular systems. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron has a delivery protein for safe storage, rather than simply drifting into every target. organism: Human PCBP1 and ferritin in yeast and human cells tissue_or_cell_type: Cytosol experimental_model: Yeast expression, in-vitro binding/loading and human-cell depletion limitations: Chaperone-mediated distribution is distinct from total cellular iron. exposure: PCBP1 expression and depletion evidence_span: {"source_cache": "artifacts/iron-research/18511687.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68", "start_char": 0, "end_char": 703, "text_sha256": "d8000e5c5f59dc72e9697d5aac77ce5070a1c92f6cada7e863088ec917684c68"} [iron-p18511687] A cytosolic iron chaperone that delivers iron to ferritin. (2008). https://pubmed.ncbi.nlm.nih.gov/18511687/ DOI: 10.1126/science.1157643
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards