Component
Parenteral B-vitamin and vitamin C preparation
Pabrinex formulation used in the 2022 alcohol-withdrawal trial; it is a multivitamin preparation, not pure thiamine.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The thiamine-containing infusion increased erythrocyte ThDP in both thiamine-treated groups at two hours.
Experimental context and source evidence
- experimental_model
- Three-arm randomized trial.
- exposure
- Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.
- limitations
- Most patients already had normal/high erythrocyte ThDP; an increase does not establish brain repletion. Pabrinex included other vitamins.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- The blood cofactor measurement rose after the thiamine-containing infusion.
- primary_references
- [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
- tissue_or_cell_type
- Erythrocytes
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1587–1597
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-arm randomized trial. · source_derived_draft · unverified_draft
### b1-aws-thiamine-raises-thdp The thiamine-containing infusion increased erythrocyte ThDP in both thiamine-treated groups at two hours. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The blood cofactor measurement rose after the thiamine-containing infusion. organism: Homo sapiens tissue_or_cell_type: Erythrocytes experimental_model: Three-arm randomized trial. limitations: Most patients already had normal/high erythrocyte ThDP; an increase does not establish brain repletion. Pabrinex included other vitamins. exposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations. [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.