{"id":"ff455033-6c7d-5fd6-9541-21cd18ffe025","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-aws-thiamine-raises-thdp","predicate":"increases","statement":"The thiamine-containing infusion increased erythrocyte ThDP in both thiamine-treated groups at two hours.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4418ee44-7c0b-5bba-a42d-b9b4b1c7a703","mechanism_event_label":"The blood cofactor measurement rose after the thiamine-containing infusion.","subject":{"id":"ee4532f7-293b-5787-9ae7-2e6b0a69493a","slug":"parenteral-b-c-vitamin-preparation","display_name":"Parenteral B-vitamin and vitamin C preparation","entity_type_key":"chemical_species"},"object":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4418ee44-7c0b-5bba-a42d-b9b4b1c7a703","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-aws-thiamine-raises-thdp-event","event_type":"observed_intervention","label":"The blood cofactor measurement rose after the thiamine-containing infusion.","description":"The thiamine-containing infusion increased erythrocyte ThDP in both thiamine-treated groups at two hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"administered_component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"187db168-8028-5ce6-9f8b-4bc61ebad1a0","slug":"thiamine-diphosphate","display_name":"Thiamine diphosphate","entity_type_key":"small_molecule"},"role":"measured_metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ee4532f7-293b-5787-9ae7-2e6b0a69493a","slug":"parenteral-b-c-vitamin-preparation","display_name":"Parenteral B-vitamin and vitamin C preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Three-arm randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Most patients already had normal/high erythrocyte ThDP; an increase does not establish brain repletion. Pabrinex included other vitamins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The blood cofactor measurement rose after the thiamine-containing infusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Erythrocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f7909dca-415a-5df3-874b-346beef26cbb","evidence_kind":"source_excerpt","locator":"Lines 1587-1597","start_line":1587,"end_line":1597,"excerpt":"### b1-aws-thiamine-raises-thdp\nThe thiamine-containing infusion increased erythrocyte ThDP in both thiamine-treated groups at two hours.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The blood cofactor measurement rose after the thiamine-containing infusion.\norganism: Homo sapiens\ntissue_or_cell_type: Erythrocytes\nexperimental_model: Three-arm randomized trial.\nlimitations: Most patients already had normal/high erythrocyte ThDP; an increase does not establish brain repletion. Pabrinex included other vitamins.\nexposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.\n[b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","model_system":"Three-arm randomized trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}