Component

Omega-3 / n-3 fatty acids, study-specified mixture

Omega-3 / n-3 fatty acids, study-specified mixture. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Dietary docosahexaenoic acid supplementation altered select physiological endocannabinoid-system metabolites in brain and plasma.

    Omega-3 / n-3 fatty acids, study-specified mixture → Brain endocannabinoid and N-acylethanolamine levels source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/20071693.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd1db87651b7b35784fcd3a50377a11cf8d9a513df35d28860b4fc4e7221a0c1", "start_char": 0, "end_char": 1580, "text_sha256": "cd1db87651b7b35784fcd3a50377a11cf8d9a513df35d28860b4fc4e7221a0c1"}
    experimental_model
    Dietary docosahexaenoic acid supplementation with brain and plasma endocannabinoid metabolite measurement
    exposure
    Dietary DHA supplementation
    limitations
    Tests the opposite manipulation to deficiency and finds selective rather than global change.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rodent
    plain_language
    Adding these fats back moves some of the messengers, not all of them.
    primary_references
    [thc-p20071693] Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma. (2010). https://pubmed.ncbi.nlm.nih.gov/20071693/ DOI: 10.1194/jlr.m002436
    tissue_or_cell_type
    Brain and plasma
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 686–697

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary docosahexaenoic acid supplementation with brain and plasma endocannabinoid metabolite measurement · source_derived_draft · unverified_draft

    ### thc-dha-alters-metabolites Dietary docosahexaenoic acid supplementation altered select physiological endocannabinoid-system metabolites in brain and plasma. Condition category: nutrient_deficiency nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Adding these fats back moves some of the messengers, not all of them. organism: Rodent tissue_or_cell_type: Brain and plasma experimental_model: Dietary docosahexaenoic acid supplementation with brain and plasma endocannabinoid metabolite measurement limitations: Tests the opposite manipulation to deficiency and finds selective rather than global change. exposure: Dietary DHA supplementation evidence_span: {"source_cache": "artifacts/thc-research/20071693.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd1db87651b7b35784fcd3a50377a11cf8d9a513df35d28860b4fc4e7221a0c1", "start_char": 0, "end_char": 1580, "text_sha256": "cd1db87651b7b35784fcd3a50377a11cf8d9a513df35d28860b4fc4e7221a0c1"} [thc-p20071693] Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma. (2010). https://pubmed.ncbi.nlm.nih.gov/20071693/ DOI: 10.1194/jlr.m002436
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Lifelong n-3 polyunsaturated fatty acid dietary insufficiency specifically ablated long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens.

    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids → Endocannabinoid-mediated long-term synaptic depression source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"}
    experimental_model
    Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays
    exposure
    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids
    limitations
    A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    Starve the diet of these fats and one specific form of synaptic learning disappears.
    primary_references
    [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    tissue_or_cell_type
    Prelimbic prefrontal cortex and accumbens
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 621–632

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays · source_derived_draft · unverified_draft

    ### thc-n3-ablates-ltd Lifelong n-3 polyunsaturated fatty acid dietary insufficiency specifically ablated long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. Condition category: nutrient_deficiency nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Starve the diet of these fats and one specific form of synaptic learning disappears. organism: Mouse tissue_or_cell_type: Prelimbic prefrontal cortex and accumbens experimental_model: Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays limitations: A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change. exposure: Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids evidence_span: {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"} [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    Complete structured claim and evidence

  2. Low n-3 intake increased parafoveal damage sensitivity relative to adequate n-3 intake.

    Low n-3 fatty-acid intake in the rhesus photodamage study → Rhesus parafoveal laser-induced photodamage susceptibility source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/lutein-research/21245404.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b", "start_char": 0, "end_char": 1712, "text_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b"}
    experimental_model
    Dietary deprivation/repletion and controlled laser challenge
    exposure
    Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures
    limitations
    Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Rhesus macaque
    plain_language
    The fatty-acid effect occurred in a different retinal region.
    primary_references
    [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898
    tissue_or_cell_type
    Foveal and parafoveal retina
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 463–474

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary deprivation/repletion and controlled laser challenge · source_derived_draft · unverified_draft

    ### lutein-n3-region Low n-3 intake increased parafoveal damage sensitivity relative to adequate n-3 intake. Condition category: nutrient_deficiency nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: The fatty-acid effect occurred in a different retinal region. organism: Rhesus macaque tissue_or_cell_type: Foveal and parafoveal retina experimental_model: Dietary deprivation/repletion and controlled laser challenge limitations: Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure. exposure: Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures evidence_span: {"source_cache": "artifacts/lutein-research/21245404.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b", "start_char": 0, "end_char": 1712, "text_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b"} [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards