Component

Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids

Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Lifelong n-3 polyunsaturated fatty acid dietary insufficiency specifically ablated long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens.

    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids → Endocannabinoid-mediated long-term synaptic depression source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"}
    experimental_model
    Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays
    exposure
    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids
    limitations
    A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    Starve the diet of these fats and one specific form of synaptic learning disappears.
    primary_references
    [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    tissue_or_cell_type
    Prelimbic prefrontal cortex and accumbens
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 621–632

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays · source_derived_draft · unverified_draft

    ### thc-n3-ablates-ltd Lifelong n-3 polyunsaturated fatty acid dietary insufficiency specifically ablated long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. Condition category: nutrient_deficiency nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Starve the diet of these fats and one specific form of synaptic learning disappears. organism: Mouse tissue_or_cell_type: Prelimbic prefrontal cortex and accumbens experimental_model: Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays limitations: A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change. exposure: Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids evidence_span: {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"} [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    Complete structured claim and evidence

  2. The dietary-induced reduction of CB1 receptor function in mood-controlling structures was associated with impaired emotional behaviour, identifying a plausible synaptic substrate for the behavioural alterations reported with n-3 deficiency in western diets.

    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids → Emotional behaviour in the tested mouse assays source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"}
    experimental_model
    Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays
    exposure
    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids
    limitations
    A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    The animals behaved differently, and the synapse gives a reason why.
    primary_references
    [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    tissue_or_cell_type
    Prelimbic prefrontal cortex and accumbens
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 647–658

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays · source_derived_draft · unverified_draft

    ### thc-n3-emotional-behaviour The dietary-induced reduction of CB1 receptor function in mood-controlling structures was associated with impaired emotional behaviour, identifying a plausible synaptic substrate for the behavioural alterations reported with n-3 deficiency in western diets. Condition category: nutrient_deficiency nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The animals behaved differently, and the synapse gives a reason why. organism: Mouse tissue_or_cell_type: Prelimbic prefrontal cortex and accumbens experimental_model: Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays limitations: A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change. exposure: Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids evidence_span: {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"} [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    Complete structured claim and evidence

  3. In n-3-deficient mice, presynaptic CB1 receptors that normally respond to endocannabinoids were uncoupled from their effector Gi/o proteins.

    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids → Coupling of presynaptic CB1 receptors to their Gi/o effector proteins source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"}
    experimental_model
    Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays
    exposure
    Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids
    limitations
    A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    The receptor was still there but no longer connected to what it talks to.
    primary_references
    [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    tissue_or_cell_type
    Prelimbic prefrontal cortex and accumbens
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 634–645

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays · source_derived_draft · unverified_draft

    ### thc-n3-uncouples-cb1 In n-3-deficient mice, presynaptic CB1 receptors that normally respond to endocannabinoids were uncoupled from their effector Gi/o proteins. Condition category: nutrient_deficiency nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor was still there but no longer connected to what it talks to. organism: Mouse tissue_or_cell_type: Prelimbic prefrontal cortex and accumbens experimental_model: Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays limitations: A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change. exposure: Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids evidence_span: {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"} [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
    Complete structured claim and evidence

In the sources

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    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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