Component
Emotional behaviour in the tested mouse assays
Emotional behaviour in the tested mouse assays. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The dietary-induced reduction of CB1 receptor function in mood-controlling structures was associated with impaired emotional behaviour, identifying a plausible synaptic substrate for the behavioural alterations reported with n-3 deficiency in western diets.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"}
- experimental_model
- Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays
- exposure
- Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids
- limitations
- A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Mouse
- plain_language
- The animals behaved differently, and the synapse gives a reason why.
- primary_references
- [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
- tissue_or_cell_type
- Prelimbic prefrontal cortex and accumbens
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 647–658
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays · source_derived_draft · unverified_draft
### thc-n3-emotional-behaviour The dietary-induced reduction of CB1 receptor function in mood-controlling structures was associated with impaired emotional behaviour, identifying a plausible synaptic substrate for the behavioural alterations reported with n-3 deficiency in western diets. Condition category: nutrient_deficiency nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The animals behaved differently, and the synapse gives a reason why. organism: Mouse tissue_or_cell_type: Prelimbic prefrontal cortex and accumbens experimental_model: Lifelong n-3 deficient diet in mice with synaptic recordings and receptor coupling assays limitations: A dietary manipulation with a molecular readout, receptor-effector uncoupling, rather than only a behavioural one. It is a lifelong deficiency, not a short-term change. exposure: Lifelong dietary insufficiency of n-3 polyunsaturated fatty acids evidence_span: {"source_cache": "artifacts/thc-research/21278728.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281", "start_char": 0, "end_char": 953, "text_sha256": "d19499dcf42cdfc31c0fc46420a1bc84babcbfcd366cf1cb37f3fed8f5d38281"} [thc-p21278728] Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. (2011). https://pubmed.ncbi.nlm.nih.gov/21278728/ DOI: 10.1038/nn.2736
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.