Component
Nutritional rickets healing
Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Calcium-containing treatment produced more biochemical and radiographic healing than vitamin D alone in the Nigerian rickets trial.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- 123 children, 24-week randomized trial; low calcium intake also present in matched controls.
- exposure
- 1000 mg elemental calcium/day, vitamin D injections, or both. Combined healing endpoint: calcium 61%, combined 58%, vitamin D 19%. Historical regimens only.
- limitations
- Does not make every case of rickets calcium-deficiency disease. The combined endpoint included alkaline phosphatase and radiographs. The injected vitamin D molecular form is not assigned here.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- In these children, replacing calcium helped heal rickets.
- primary_references
- [cal-clin-thacher1999] A Comparison of Calcium, Vitamin D, or Both for Nutritional Rickets in Nigerian Children (1999). https://www.nejm.org/doi/full/10.1056/NEJM199908193410803 DOI: 10.1056/NEJM199908193410803
- tissue_or_cell_type
- Human clinical or absorption endpoint
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 1187–1197
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 123 children, 24-week randomized trial; low calcium intake also present in matched controls. · source_derived_draft · unverified_draft
### cal-rickets-repletion Calcium-containing treatment produced more biochemical and radiographic healing than vitamin D alone in the Nigerian rickets trial. Condition category: nutrient_deficiency nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: In these children, replacing calcium helped heal rickets. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 123 children, 24-week randomized trial; low calcium intake also present in matched controls. limitations: Does not make every case of rickets calcium-deficiency disease. The combined endpoint included alkaline phosphatase and radiographs. The injected vitamin D molecular form is not assigned here. exposure: 1000 mg elemental calcium/day, vitamin D injections, or both. Combined healing endpoint: calcium 61%, combined 58%, vitamin D 19%. Historical regimens only. [cal-clin-thacher1999] A Comparison of Calcium, Vitamin D, or Both for Nutritional Rickets in Nigerian Children (1999). https://www.nejm.org/doi/full/10.1056/NEJM199908193410803 DOI: 10.1056/NEJM199908193410803
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.