{"id":"0ecb8555-1884-54ad-84e2-8a45e9823592","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-rickets-repletion","predicate":"has_reported_effect_on","statement":"Calcium-containing treatment produced more biochemical and radiographic healing than vitamin D alone in the Nigerian rickets trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"fb9dded4-107e-5c05-bd52-ee499b133165","mechanism_event_label":"In these children, replacing calcium helped heal rickets.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"4bf5b972-d50e-59ee-af52-625634dc4d85","slug":"nutritional-rickets-healing","display_name":"Nutritional rickets healing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fb9dded4-107e-5c05-bd52-ee499b133165","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-rickets-repletion-event","event_type":"observed_intervention","label":"In these children, replacing calcium helped heal rickets.","description":"Calcium-containing treatment produced more biochemical and radiographic healing than vitamin D alone in the Nigerian rickets trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4bf5b972-d50e-59ee-af52-625634dc4d85","slug":"nutritional-rickets-healing","display_name":"Nutritional rickets healing","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4ee1cbd0-1cec-58e1-9fee-bdb2c13db94d","slug":"calcium-carbonate","display_name":"Calcium carbonate","entity_type_key":"chemical_species"},"role":"calcium_form","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"123 children, 24-week randomized trial; low calcium intake also present in matched controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1000 mg elemental calcium/day, vitamin D injections, or both. Combined healing endpoint: calcium 61%, combined 58%, vitamin D 19%. Historical regimens only.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not make every case of rickets calcium-deficiency disease. The combined endpoint included alkaline phosphatase and radiographs. The injected vitamin D molecular form is not assigned here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In these children, replacing calcium helped heal rickets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-thacher1999] A Comparison of Calcium, Vitamin D, or Both for Nutritional Rickets in Nigerian Children (1999). https://www.nejm.org/doi/full/10.1056/NEJM199908193410803 DOI: 10.1056/NEJM199908193410803","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c0c723b0-b310-5c06-a7d1-bd518ae290c4","evidence_kind":"source_excerpt","locator":"Lines 1187-1197","start_line":1187,"end_line":1197,"excerpt":"### cal-rickets-repletion\nCalcium-containing treatment produced more biochemical and radiographic healing than vitamin D alone in the Nigerian rickets trial.\nCondition category: nutrient_deficiency\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In these children, replacing calcium helped heal rickets.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: 123 children, 24-week randomized trial; low calcium intake also present in matched controls.\nlimitations: Does not make every case of rickets calcium-deficiency disease. The combined endpoint included alkaline phosphatase and radiographs. The injected vitamin D molecular form is not assigned here.\nexposure: 1000 mg elemental calcium/day, vitamin D injections, or both. Combined healing endpoint: calcium 61%, combined 58%, vitamin D 19%. Historical regimens only.\n[cal-clin-thacher1999] A Comparison of Calcium, Vitamin D, or Both for Nutritional Rickets in Nigerian Children (1999). https://www.nejm.org/doi/full/10.1056/NEJM199908193410803 DOI: 10.1056/NEJM199908193410803","model_system":"123 children, 24-week randomized trial; low calcium intake also present in matched controls.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-thacher1999] A Comparison of Calcium, Vitamin D, or Both for Nutritional Rickets in Nigerian Children (1999). https://www.nejm.org/doi/full/10.1056/NEJM199908193410803 DOI: 10.1056/NEJM199908193410803","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}