Component
Human circulating non-transferrin-bound iron concentration
Human circulating non-transferrin-bound iron concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adjusted non-transferrin-bound iron was lower with curcumin than placebo at trial end.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/29806132.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c", "start_char": 0, "end_char": 1511, "text_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c"}
- experimental_model
- Double-blind randomized trial in 68 beta-thalassemia major patients
- exposure
- Two 500-mg capsules per day, total 1000 mg/day, for 12 weeks; placebo comparison
- limitations
- Disease-specific adjunctive experiment. Lower NTBI is not proof that standard chelation can be replaced or that hepcidin mediates the change.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Homo sapiens
- plain_language
- One circulating iron fraction decreased in this patient group.
- primary_references
- [curcumin-p29806132] An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29806132/ DOI: 10.1002/ptr.6118
- tissue_or_cell_type
- Circulating iron markers
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 749–760
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized trial in 68 beta-thalassemia major patients · source_derived_draft · unverified_draft
### curcumin-thal-ntbi Adjusted non-transferrin-bound iron was lower with curcumin than placebo at trial end. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: One circulating iron fraction decreased in this patient group. organism: Homo sapiens tissue_or_cell_type: Circulating iron markers experimental_model: Double-blind randomized trial in 68 beta-thalassemia major patients limitations: Disease-specific adjunctive experiment. Lower NTBI is not proof that standard chelation can be replaced or that hepcidin mediates the change. exposure: Two 500-mg capsules per day, total 1000 mg/day, for 12 weeks; placebo comparison evidence_span: {"source_cache": "artifacts/curcumin-research/29806132.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c", "start_char": 0, "end_char": 1511, "text_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c"} [curcumin-p29806132] An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29806132/ DOI: 10.1002/ptr.6118
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.