Intact nasunin exposure in rat plasma: molecular mechanisms & dependencies

How nutrients influence it

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Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Oral cis-nasunin appeared in plasma in its original acylated form, peaking at 15 minutes.
cis-Nasunin → Intact nasunin exposure in rat plasma source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/nasunin-research/16848510.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a", "start_char": 0, "end_char": 1308, "text_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a"}
experimental_model
Oral isomer pharmacokinetics with chromatographic metabolite analysis
exposure
Oral purified cis/trans nasunin; plasma follow-up to 8 h
limitations
Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion.
nutrient_topic
Nasunin research collection; topical membership is not evidence of a direct dietary effect. · Nasunin
organism
Rats
plain_language
The rat absorbed some intact pigment.
primary_references
[nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s
tissue_or_cell_type
Plasma and urine
Nasunin: identity, redox chemistry and nutrient connections (2026-09-17) · lines 718–729
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Oral isomer pharmacokinetics with chromatographic metabolite analysis · source_derived_draft · unverified_draft
### nasunin-cis-uptake Oral cis-nasunin appeared in plasma in its original acylated form, peaking at 15 minutes. Condition category: normal nutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The rat absorbed some intact pigment. organism: Rats tissue_or_cell_type: Plasma and urine experimental_model: Oral isomer pharmacokinetics with chromatographic metabolite analysis limitations: Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion. exposure: Oral purified cis/trans nasunin; plasma follow-up to 8 h evidence_span: {"source_cache": "artifacts/nasunin-research/16848510.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a", "start_char": 0, "end_char": 1308, "text_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a"} [nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s
Complete structured claim and evidence
Oral trans-nasunin also peaked as intact acylated pigment at 15 minutes.
trans-Nasunin → Intact nasunin exposure in rat plasma source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/nasunin-research/16848510.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a", "start_char": 0, "end_char": 1308, "text_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a"}
experimental_model
Oral isomer pharmacokinetics with chromatographic metabolite analysis
exposure
Oral purified cis/trans nasunin; plasma follow-up to 8 h
limitations
Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion.
nutrient_topic
Nasunin research collection; topical membership is not evidence of a direct dietary effect. · Nasunin
organism
Rats
plain_language
The second form was also detected without prior deacylation.
primary_references
[nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s
tissue_or_cell_type
Plasma and urine
Nasunin: identity, redox chemistry and nutrient connections (2026-09-17) · lines 731–742
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Oral isomer pharmacokinetics with chromatographic metabolite analysis · source_derived_draft · unverified_draft
### nasunin-trans-uptake Oral trans-nasunin also peaked as intact acylated pigment at 15 minutes. Condition category: normal nutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The second form was also detected without prior deacylation. organism: Rats tissue_or_cell_type: Plasma and urine experimental_model: Oral isomer pharmacokinetics with chromatographic metabolite analysis limitations: Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion. exposure: Oral purified cis/trans nasunin; plasma follow-up to 8 h evidence_span: {"source_cache": "artifacts/nasunin-research/16848510.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a", "start_char": 0, "end_char": 1308, "text_sha256": "72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a"} [nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s
Complete structured claim and evidence

The events it takes part in

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Situations it appears in

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In the sources

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Open hypotheses

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Intact nasunin exposure in rat plasma