Component

Nadolol

Study-scoped entity; inspect species, exposure, model and limitations on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Green tea attenuated nadolol-associated blood-pressure reduction in the volunteer study.

    Green tea beverage, study-specific mixture → Blood-pressure lowering response to nadolol source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Same 10-person tea/water comparison.
    limitations
    Not a study of cardiovascular events or isolated EGCG.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    The pharmacokinetic interaction also affected a drug response.
    primary_references
    Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 476–482

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same 10-person tea/water comparison. · source_derived_draft · unverified_draft

    ## egcg-nadolol-bp The pharmacokinetic interaction also affected a drug response. Green tea attenuated nadolol-associated blood-pressure reduction in the volunteer study. Model: Same 10-person tea/water comparison. Limitations: Not a study of cardiovascular events or isolated EGCG. Evidence access: primary abstract. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241
    Complete structured claim and evidence

  2. After 700 mL/day green tea for 14 days, nadolol Cmax and AUC fell by 85.3% and 85.0% in 10 healthy volunteers; renal clearance was unchanged.

    Green tea beverage, study-specific mixture → Nadolol plasma exposure source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    30 mg nadolol after tea versus water.
    limitations
    This human experiment tested tea, not isolated EGCG.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    Whole green tea substantially reduced exposure to nadolol.
    primary_references
    Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 468–474

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · 30 mg nadolol after tea versus water. · source_derived_draft · unverified_draft

    ## egcg-nadolol-human Whole green tea substantially reduced exposure to nadolol. After 700 mL/day green tea for 14 days, nadolol Cmax and AUC fell by 85.3% and 85.0% in 10 healthy volunteers; renal clearance was unchanged. Model: 30 mg nadolol after tea versus water. Limitations: This human experiment tested tea, not isolated EGCG. Evidence access: primary abstract. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241
    Complete structured claim and evidence

  3. EGCG pretreatment reduced rat nadolol Cmax by 53% and AUC by 51%, with weaker blood-pressure control.

    Epigallocatechin-3-gallate (EGCG) → Nadolol plasma exposure source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Male spontaneously hypertensive rats; EGCG 10 mg/kg/day for 14 days and nadolol 10 mg/kg on day 14.
    limitations
    Rat transcription/exposure results; mRNA changes do not establish transporter protein activity or a human effect size.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    Purified EGCG also changed nadolol exposure in an animal study.
    primary_references
    Oral epigallocatechin gallate reduces intestinal nadolol absorption via modulation of Oatp1a5 and Oct1 transcriptional levels in spontaneously hypertensive rats. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34303263/ · DOI 10.1016/j.phymed.2021.153623

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 492–498

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Male spontaneously hypertensive rats; EGCG 10 mg/kg/day for 14 days and nadolol 10 mg/kg on day 14. · source_derived_draft · unverified_draft

    ## egcg-nadolol-rat Purified EGCG also changed nadolol exposure in an animal study. EGCG pretreatment reduced rat nadolol Cmax by 53% and AUC by 51%, with weaker blood-pressure control. Model: Male spontaneously hypertensive rats; EGCG 10 mg/kg/day for 14 days and nadolol 10 mg/kg on day 14. Limitations: Rat transcription/exposure results; mRNA changes do not establish transporter protein activity or a human effect size. Evidence access: primary abstract. Oral epigallocatechin gallate reduces intestinal nadolol absorption via modulation of Oatp1a5 and Oct1 transcriptional levels in spontaneously hypertensive rats. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34303263/ · DOI 10.1016/j.phymed.2021.153623
    Complete structured claim and evidence

  4. Green tea inhibited OATP1A2-mediated nadolol uptake in HEK293 transport assays, supporting a possible intestinal explanation.

    Green tea beverage, study-specific mixture → Human OATP1A2 / SLCO1A2 source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    OATP1A2-transfected cells; nadolol transport Km 84.3 micromolar.
    limitations
    The clinical study did not directly prove intestinal OATP1A2 inhibition.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    A transporter experiment supplies a candidate mechanism.
    primary_references
    Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 484–490

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · OATP1A2-transfected cells; nadolol transport Km 84.3 micromolar. · source_derived_draft · unverified_draft

    ## egcg-oatp A transporter experiment supplies a candidate mechanism. Green tea inhibited OATP1A2-mediated nadolol uptake in HEK293 transport assays, supporting a possible intestinal explanation. Model: OATP1A2-transfected cells; nadolol transport Km 84.3 micromolar. Limitations: The clinical study did not directly prove intestinal OATP1A2 inhibition. Evidence access: primary abstract. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards