{"id":"cf265509-c9c6-5eb0-a24f-669395da9938","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-nadolol-bp","predicate":"attenuates","statement":"Green tea attenuated nadolol-associated blood-pressure reduction in the volunteer study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b2448df3-f137-5add-9bb0-fc1e5163e9d6","mechanism_event_label":"The pharmacokinetic interaction also affected a drug response.","subject":{"id":"3115fd3f-e4d8-568d-8d12-ffb58130aa25","slug":"green-tea-beverage","display_name":"Green tea beverage, study-specific mixture","entity_type_key":"chemical_species"},"object":{"id":"edc3e085-b52f-5665-b79c-2f8fc5cb9d3b","slug":"nadolol-blood-pressure-response","display_name":"Blood-pressure lowering response to nadolol","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b2448df3-f137-5add-9bb0-fc1e5163e9d6","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-nadolol-bp-event","event_type":"observed_relationship","label":"The pharmacokinetic interaction also affected a drug response.","description":"Green tea attenuated nadolol-associated blood-pressure reduction in the volunteer study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3115fd3f-e4d8-568d-8d12-ffb58130aa25","slug":"green-tea-beverage","display_name":"Green tea beverage, study-specific mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"edc3e085-b52f-5665-b79c-2f8fc5cb9d3b","slug":"nadolol-blood-pressure-response","display_name":"Blood-pressure lowering response to nadolol","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3604fdc-509f-5137-b727-828a523be7c4","slug":"nadolol","display_name":"Nadolol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Same 10-person tea/water comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a study of cardiovascular events or isolated EGCG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The pharmacokinetic interaction also affected a drug response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"12e4ea11-81cb-594d-8884-9133f93c9c12","evidence_kind":"source_excerpt","locator":"Lines 476-482","start_line":476,"end_line":482,"excerpt":"## egcg-nadolol-bp\nThe pharmacokinetic interaction also affected a drug response.\nGreen tea attenuated nadolol-associated blood-pressure reduction in the volunteer study.\nModel: Same 10-person tea/water comparison.\nLimitations: Not a study of cardiovascular events or isolated EGCG.\nEvidence access: primary abstract.\nGreen tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241","model_system":"Same 10-person tea/water comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}