{"id":"a710f429-835d-51ff-b0e6-32e06f39f45a","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-nadolol-human","predicate":"reduces","statement":"After 700 mL/day green tea for 14 days, nadolol Cmax and AUC fell by 85.3% and 85.0% in 10 healthy volunteers; renal clearance was unchanged.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ae14c660-d1e6-54cb-866f-ed5b8f99acdc","mechanism_event_label":"Whole green tea substantially reduced exposure to nadolol.","subject":{"id":"3115fd3f-e4d8-568d-8d12-ffb58130aa25","slug":"green-tea-beverage","display_name":"Green tea beverage, study-specific mixture","entity_type_key":"chemical_species"},"object":{"id":"06d1dce5-9406-5b80-ba0a-30b8386a19c8","slug":"nadolol-plasma-exposure","display_name":"Nadolol plasma exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ae14c660-d1e6-54cb-866f-ed5b8f99acdc","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-nadolol-human-event","event_type":"observed_relationship","label":"Whole green tea substantially reduced exposure to nadolol.","description":"After 700 mL/day green tea for 14 days, nadolol Cmax and AUC fell by 85.3% and 85.0% in 10 healthy volunteers; renal clearance was unchanged.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3115fd3f-e4d8-568d-8d12-ffb58130aa25","slug":"green-tea-beverage","display_name":"Green tea beverage, study-specific mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"06d1dce5-9406-5b80-ba0a-30b8386a19c8","slug":"nadolol-plasma-exposure","display_name":"Nadolol plasma exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3604fdc-509f-5137-b727-828a523be7c4","slug":"nadolol","display_name":"Nadolol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"30 mg nadolol after tea versus water.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This human experiment tested tea, not isolated EGCG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Whole green tea substantially reduced exposure to nadolol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3d23d028-9d45-5059-82d9-6b5c1bf16789","evidence_kind":"source_excerpt","locator":"Lines 468-474","start_line":468,"end_line":474,"excerpt":"## egcg-nadolol-human\nWhole green tea substantially reduced exposure to nadolol.\nAfter 700 mL/day green tea for 14 days, nadolol Cmax and AUC fell by 85.3% and 85.0% in 10 healthy volunteers; renal clearance was unchanged.\nModel: 30 mg nadolol after tea versus water.\nLimitations: This human experiment tested tea, not isolated EGCG.\nEvidence access: primary abstract.\nGreen tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241","model_system":"30 mg nadolol after tea versus water.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}