{"id":"4ff19ce1-aff8-51b2-a738-05e56f30e1a0","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-oatp","predicate":"inhibits","statement":"Green tea inhibited OATP1A2-mediated nadolol uptake in HEK293 transport assays, supporting a possible intestinal explanation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"383d45c5-3d53-5469-9831-de8854e1de98","mechanism_event_label":"A transporter experiment supplies a candidate mechanism.","subject":{"id":"3115fd3f-e4d8-568d-8d12-ffb58130aa25","slug":"green-tea-beverage","display_name":"Green tea beverage, study-specific mixture","entity_type_key":"chemical_species"},"object":{"id":"513046f9-cb62-583b-bfc6-eefb90a7dcae","slug":"slco1a2","display_name":"Human OATP1A2 / SLCO1A2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"383d45c5-3d53-5469-9831-de8854e1de98","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-oatp-event","event_type":"observed_relationship","label":"A transporter experiment supplies a candidate mechanism.","description":"Green tea inhibited OATP1A2-mediated nadolol uptake in HEK293 transport assays, supporting a possible intestinal explanation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3115fd3f-e4d8-568d-8d12-ffb58130aa25","slug":"green-tea-beverage","display_name":"Green tea beverage, study-specific mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"513046f9-cb62-583b-bfc6-eefb90a7dcae","slug":"slco1a2","display_name":"Human OATP1A2 / SLCO1A2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3604fdc-509f-5137-b727-828a523be7c4","slug":"nadolol","display_name":"Nadolol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"OATP1A2-transfected cells; nadolol transport Km 84.3 micromolar.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The clinical study did not directly prove intestinal OATP1A2 inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A transporter experiment supplies a candidate mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7857f111-3f8c-5791-b2f0-37eeefb09b21","evidence_kind":"source_excerpt","locator":"Lines 484-490","start_line":484,"end_line":490,"excerpt":"## egcg-oatp\nA transporter experiment supplies a candidate mechanism.\nGreen tea inhibited OATP1A2-mediated nadolol uptake in HEK293 transport assays, supporting a possible intestinal explanation.\nModel: OATP1A2-transfected cells; nadolol transport Km 84.3 micromolar.\nLimitations: The clinical study did not directly prove intestinal OATP1A2 inhibition.\nEvidence access: primary abstract.\nGreen tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24419562/ · DOI 10.1038/clpt.2013.241","model_system":"OATP1A2-transfected cells; nadolol transport Km 84.3 micromolar.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}