Component

Mtrr gene (Mus musculus)

Mouse gene targeted by a hypomorphic gene trap.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Hypomorphic Mtrr gt/gt mice had higher plasma homocysteine than controls.

    Mtrr gene (Mus musculus) → Homocysteine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Mtrr gene-trap hypomorphic mice and controls.
    limitations
    Not all human MTRR variants.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Mus musculus
    plain_language
    Partial reactivation failure impaired homocysteine handling.
    primary_references
    [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    tissue_or_cell_type
    Plasma
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 566–575

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mtrr gene-trap hypomorphic mice and controls. · source_derived_draft · unverified_draft

    ### folate-methyl-mtrr-mouse-hcy Hypomorphic Mtrr gt/gt mice had higher plasma homocysteine than controls. Condition category: machinery_impairment nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Partial reactivation failure impaired homocysteine handling. organism: Mus musculus tissue_or_cell_type: Plasma experimental_model: Mtrr gene-trap hypomorphic mice and controls. limitations: Not all human MTRR variants. [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    Complete structured claim and evidence

  2. Mtrr gt/gt mice had lower plasma methionine than controls.

    Mtrr gene (Mus musculus) → L-Methionine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Mtrr gene-trap hypomorphic mice and controls.
    limitations
    Not a direct tissue methylation assay.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Mus musculus
    plain_language
    The same defect reduced circulating methionine.
    primary_references
    [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    tissue_or_cell_type
    Plasma
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 577–586

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mtrr gene-trap hypomorphic mice and controls. · source_derived_draft · unverified_draft

    ### folate-methyl-mtrr-mouse-met Mtrr gt/gt mice had lower plasma methionine than controls. Condition category: machinery_impairment nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same defect reduced circulating methionine. organism: Mus musculus tissue_or_cell_type: Plasma experimental_model: Mtrr gene-trap hypomorphic mice and controls. limitations: Not a direct tissue methylation assay. [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    Complete structured claim and evidence

  3. Mtrr gt/gt mice showed increased tissue methyltetrahydrofolate.

    Mtrr gene (Mus musculus) → 5-Methyltetrahydrofolate source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Mtrr gene-trap hypomorphic mice and controls.
    limitations
    Abstract-level tissue aggregate; no universal fold change.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Mus musculus
    plain_language
    Reduced reductase function altered folate distribution.
    primary_references
    [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    tissue_or_cell_type
    Tissue extracts
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 599–608

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mtrr gene-trap hypomorphic mice and controls. · source_derived_draft · unverified_draft

    ### folate-methyl-mtrr-mouse-methylfolate Mtrr gt/gt mice showed increased tissue methyltetrahydrofolate. Condition category: machinery_impairment nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Reduced reductase function altered folate distribution. organism: Mus musculus tissue_or_cell_type: Tissue extracts experimental_model: Mtrr gene-trap hypomorphic mice and controls. limitations: Abstract-level tissue aggregate; no universal fold change. [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    Complete structured claim and evidence

  4. Mtrr gene-trap mice did not show decreased SAM:SAH ratios in most tissues despite disturbed remethylation.

    Mtrr gene (Mus musculus) → SAM:SAH concentration ratio source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Mtrr gene-trap hypomorphic mice and controls.
    limitations
    Ratio is not DNA methylation.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Mus musculus
    plain_language
    The ratio did not fall uniformly.
    primary_references
    [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    tissue_or_cell_type
    Assayed tissue panel
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 588–597

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mtrr gene-trap hypomorphic mice and controls. · source_derived_draft · unverified_draft

    ### folate-methyl-mtrr-mouse-ratio Mtrr gene-trap mice did not show decreased SAM:SAH ratios in most tissues despite disturbed remethylation. Condition category: machinery_impairment nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The ratio did not fall uniformly. organism: Mus musculus tissue_or_cell_type: Assayed tissue panel experimental_model: Mtrr gene-trap hypomorphic mice and controls. limitations: Ratio is not DNA methylation. [elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards