{"id":"76999d7c-a8c9-56d3-be9c-69994726e84b","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-mtrr-mouse-methylfolate","predicate":"impairment_increases","statement":"Mtrr gt/gt mice showed increased tissue methyltetrahydrofolate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"86e46958-7e17-51b0-9736-cdda8a1357b4","mechanism_event_label":"Reduced reductase function altered folate distribution.","subject":{"id":"db2f9c35-40d4-5c0d-a225-d9d292b717f6","slug":"mtrr-mouse-gene","display_name":"Mtrr gene (Mus musculus)","entity_type_key":"gene"},"object":{"id":"23f48782-478e-5f62-874a-31273c075fe7","slug":"5-methyltetrahydrofolate","display_name":"5-Methyltetrahydrofolate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"86e46958-7e17-51b0-9736-cdda8a1357b4","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-mtrr-mouse-methylfolate-event","event_type":"biochemical_relationship","label":"Reduced reductase function altered folate distribution.","description":"Mtrr gt/gt mice showed increased tissue methyltetrahydrofolate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"db2f9c35-40d4-5c0d-a225-d9d292b717f6","slug":"mtrr-mouse-gene","display_name":"Mtrr gene (Mus musculus)","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"23f48782-478e-5f62-874a-31273c075fe7","slug":"5-methyltetrahydrofolate","display_name":"5-Methyltetrahydrofolate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Mtrr gene-trap hypomorphic mice and controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract-level tissue aggregate; no universal fold change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Reduced reductase function altered folate distribution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Tissue extracts","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"8c9635a8-ff3c-501e-bb2d-7db0188bb9df","evidence_kind":"source_excerpt","locator":"Lines 599-608","start_line":599,"end_line":608,"excerpt":"### folate-methyl-mtrr-mouse-methylfolate\nMtrr gt/gt mice showed increased tissue methyltetrahydrofolate.\nCondition category: machinery_impairment\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Reduced reductase function altered folate distribution.\norganism: Mus musculus\ntissue_or_cell_type: Tissue extracts\nexperimental_model: Mtrr gene-trap hypomorphic mice and controls.\nlimitations: Abstract-level tissue aggregate; no universal fold change.\n[elmore-2007] Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase (2007). https://pubmed.ncbi.nlm.nih.gov/17369066/ DOI: 10.1016/j.ymgme.2007.02.001","model_system":"Mtrr gene-trap hypomorphic mice and controls.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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