Component
Growth and proliferation during mouse T-cell activation
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Activation increased SNAT1 transcript and protein in mouse T cells alongside their increased requirement for extracellular alanine.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Primary mouse naive CD4/CD8 cells activated ex vivo; dialyzed-serum medium with alanine add-back.
- limitations
- Expression was measured; this experiment did not genetically prove that SNAT1 alone accounts for alanine uptake.
- nutrient_topic
- L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Alanine
- plain_language
- Activated cells increase machinery for bringing alanine inside.
- primary_references
- T Cell Activation Depends on Extracellular Alanine. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31533027/ · DOI 10.1016/j.celrep.2019.08.034
L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19) · lines 88–94
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary mouse naive CD4/CD8 cells activated ex vivo; dialyzed-serum medium with alanine add-back. · source_derived_draft · unverified_draft
## alanine-t-cell-transport Activated cells increase machinery for bringing alanine inside. Activation increased SNAT1 transcript and protein in mouse T cells alongside their increased requirement for extracellular alanine. Model: Primary mouse naive CD4/CD8 cells activated ex vivo; dialyzed-serum medium with alanine add-back. Limitations: Expression was measured; this experiment did not genetically prove that SNAT1 alone accounts for alanine uptake. Evidence access: Primary full text T Cell Activation Depends on Extracellular Alanine. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31533027/ · DOI 10.1016/j.celrep.2019.08.034
Complete structured claim and evidence
What acts on it
Alanine add-back restored growth and proliferation impaired by dialyzed-serum culture during initial activation of mouse naive T cells.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Primary mouse naive CD4/CD8 cells activated ex vivo; dialyzed-serum medium with alanine add-back.
- limitations
- Dialysis removes multiple small nutrients; alanine rescue supports its contribution. This does not establish a human dietary deficiency or immune-boosting dose.
- nutrient_topic
- L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Alanine
- plain_language
- A cell may be able to make alanine yet fail to make it fast enough when demand rises.
- primary_references
- T Cell Activation Depends on Extracellular Alanine. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31533027/ · DOI 10.1016/j.celrep.2019.08.034
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19) · lines 80–86
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary mouse naive CD4/CD8 cells activated ex vivo; dialyzed-serum medium with alanine add-back. · source_derived_draft · unverified_draft
## alanine-t-cell-growth A cell may be able to make alanine yet fail to make it fast enough when demand rises. Alanine add-back restored growth and proliferation impaired by dialyzed-serum culture during initial activation of mouse naive T cells. Model: Primary mouse naive CD4/CD8 cells activated ex vivo; dialyzed-serum medium with alanine add-back. Limitations: Dialysis removes multiple small nutrients; alanine rescue supports its contribution. This does not establish a human dietary deficiency or immune-boosting dose. Evidence access: Primary full text T Cell Activation Depends on Extracellular Alanine. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31533027/ · DOI 10.1016/j.celrep.2019.08.034
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.