Component
Mouse amino-acid transporter ATB0,+ / Slc6a14
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Expressing mouse ATB0,+ in HRPE cells enabled carnitine transport requiring both sodium and chloride; activation analysis was consistent with two sodium ions and one chloride ion.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse colon transporter expressed in human retinal pigment epithelial cells and frog oocytes.
- limitations
- The transporter is mouse-derived even in a human host cell; dietary sodium/chloride effects were not tested.
- nutrient_topic
- L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit. · L-Carnitine
- plain_language
- A second uptake route couples carnitine to both salt ions.
- primary_references
- Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11306651/ · DOI 10.1111/j.1469-7793.2001.0297f.x
- transport_effect
- raises Carnitine transport requiring both sodium and chloride, which is inward.
- transport_pool
- the expressing cell Carnitine transport requiring both sodium and chloride, which is inward.
L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19) · lines 466–472
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse colon transporter expressed in human retinal pigment epithelial cells and frog oocytes. · source_derived_draft · unverified_draft
## l-carnitine-atb-carnitine A second uptake route couples carnitine to both salt ions. Expressing mouse ATB0,+ in HRPE cells enabled carnitine transport requiring both sodium and chloride; activation analysis was consistent with two sodium ions and one chloride ion. Model: Mouse colon transporter expressed in human retinal pigment epithelial cells and frog oocytes. Limitations: The transporter is mouse-derived even in a human host cell; dietary sodium/chloride effects were not tested. Evidence access: Primary abstract Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11306651/ · DOI 10.1111/j.1469-7793.2001.0297f.x
Complete structured claim and evidenceAmino-acid substrates inhibited carnitine transport through expressed mouse ATB0,+.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse Slc6a14 heterologous expression assays.
- limitations
- This finding concerns ATB0,+, not OCTN2; in vitro competition does not establish a meal or supplement interaction.
- nutrient_topic
- L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit. · L-Carnitine
- plain_language
- Some amino acids share and compete for this transport route.
- primary_references
- Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11306651/ · DOI 10.1111/j.1469-7793.2001.0297f.x
L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19) · lines 474–480
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse Slc6a14 heterologous expression assays. · source_derived_draft · unverified_draft
## l-carnitine-atb-competition Some amino acids share and compete for this transport route. Amino-acid substrates inhibited carnitine transport through expressed mouse ATB0,+. Model: Mouse Slc6a14 heterologous expression assays. Limitations: This finding concerns ATB0,+, not OCTN2; in vitro competition does not establish a meal or supplement interaction. Evidence access: Primary abstract Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11306651/ · DOI 10.1111/j.1469-7793.2001.0297f.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.