{"id":"6bbe3b13-a729-5684-aef3-5365a1bf8442","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-atb-competition","predicate":"has_competitive","statement":"Amino-acid substrates inhibited carnitine transport through expressed mouse ATB0,+.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e2b0813f-db3a-5b5d-bead-a4a72d3dfa18","mechanism_event_label":"Some amino acids share and compete for this transport route.","subject":{"id":"b6a4708a-bb18-5557-8e3c-644024c4eb22","slug":"mouse-slc6a14","display_name":"Mouse amino-acid transporter ATB0,+ / Slc6a14","entity_type_key":"protein"},"object":{"id":"f8f60f31-ad4e-546f-bb21-91c5b7bd4154","slug":"mouse-atb-carnitine-transport","display_name":"Mouse ATB0,+-mediated carnitine transport","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2b0813f-db3a-5b5d-bead-a4a72d3dfa18","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-atb-competition-event","event_type":"observed_relationship","label":"Some amino acids share and compete for this transport route.","description":"Amino-acid substrates inhibited carnitine transport through expressed mouse ATB0,+.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b6a4708a-bb18-5557-8e3c-644024c4eb22","slug":"mouse-slc6a14","display_name":"Mouse amino-acid transporter ATB0,+ / Slc6a14","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f8f60f31-ad4e-546f-bb21-91c5b7bd4154","slug":"mouse-atb-carnitine-transport","display_name":"Mouse ATB0,+-mediated carnitine transport","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse Slc6a14 heterologous expression assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This finding concerns ATB0,+, not OCTN2; in vitro competition does not establish a meal or supplement interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Some amino acids share and compete for this transport route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11306651/ · DOI 10.1111/j.1469-7793.2001.0297f.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8f904454-c10d-50c3-a90f-82ce38cd5c06","evidence_kind":"source_excerpt","locator":"Lines 474-480","start_line":474,"end_line":480,"excerpt":"## l-carnitine-atb-competition\nSome amino acids share and compete for this transport route.\nAmino-acid substrates inhibited carnitine transport through expressed mouse ATB0,+.\nModel: Mouse Slc6a14 heterologous expression assays.\nLimitations: This finding concerns ATB0,+, not OCTN2; in vitro competition does not establish a meal or supplement interaction.\nEvidence access: Primary abstract\nNa+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11306651/ · DOI 10.1111/j.1469-7793.2001.0297f.x","model_system":"Mouse Slc6a14 heterologous expression assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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