Component
Mouse Slc5a3 (SMIT1)
Mouse Slc5a3 (SMIT1). Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The original report described profound brain myo-inositol deficiency in its lethal mouse transport-loss model.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/inositol-research/15110328.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee", "start_char": 0, "end_char": 1202, "text_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee"}
- experimental_model
- Transporter knockout and brain chemical analysis
- exposure
- SMIT1-null mice
- limitations
- Severe genetic transport failure is not dietary deficiency. Unchanged total PI does not rule out local phosphoinositide abnormalities. An indexed erratum exists (10.1016/j.ymgme.2004.06.012); its content was not retrievable during this curation, so these findings remain provisional reports from the indexed original abstract.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Mus musculus
- plain_language
- Loss of a transport route caused a major free-inositol deficit in this reported model.
- primary_references
- [ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002
- tissue_or_cell_type
- Brain
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 431–442
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter knockout and brain chemical analysis · source_derived_draft · unverified_draft
### ino-smit1-low-pool The original report described profound brain myo-inositol deficiency in its lethal mouse transport-loss model. Condition category: machinery_impairment nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of a transport route caused a major free-inositol deficit in this reported model. organism: Mus musculus tissue_or_cell_type: Brain experimental_model: Transporter knockout and brain chemical analysis limitations: Severe genetic transport failure is not dietary deficiency. Unchanged total PI does not rule out local phosphoinositide abnormalities. An indexed erratum exists (10.1016/j.ymgme.2004.06.012); its content was not retrievable during this curation, so these findings remain provisional reports from the indexed original abstract. exposure: SMIT1-null mice evidence_span: {"source_cache": "artifacts/inositol-research/15110328.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee", "start_char": 0, "end_char": 1202, "text_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee"} [ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002
Complete structured claim and evidenceDespite severely reduced brain myo-inositol, measured brain phosphatidylinositol was not decreased in SMIT1-null mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/inositol-research/15110328.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee", "start_char": 0, "end_char": 1202, "text_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee"}
- experimental_model
- Transporter knockout and brain chemical analysis
- exposure
- SMIT1-null mice
- limitations
- Severe genetic transport failure is not dietary deficiency. Unchanged total PI does not rule out local phosphoinositide abnormalities. An indexed erratum exists (10.1016/j.ymgme.2004.06.012); its content was not retrievable during this curation, so these findings remain provisional reports from the indexed original abstract.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Mus musculus
- plain_language
- The free pool and the total membrane-lipid pool did not fall together.
- primary_references
- [ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002
- tissue_or_cell_type
- Brain
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 444–455
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter knockout and brain chemical analysis · source_derived_draft · unverified_draft
### ino-smit1-pi-preserved Despite severely reduced brain myo-inositol, measured brain phosphatidylinositol was not decreased in SMIT1-null mice. Condition category: machinery_impairment nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The free pool and the total membrane-lipid pool did not fall together. organism: Mus musculus tissue_or_cell_type: Brain experimental_model: Transporter knockout and brain chemical analysis limitations: Severe genetic transport failure is not dietary deficiency. Unchanged total PI does not rule out local phosphoinositide abnormalities. An indexed erratum exists (10.1016/j.ymgme.2004.06.012); its content was not retrievable during this curation, so these findings remain provisional reports from the indexed original abstract. exposure: SMIT1-null mice evidence_span: {"source_cache": "artifacts/inositol-research/15110328.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee", "start_char": 0, "end_char": 1202, "text_sha256": "efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee"} [ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.