{"id":"d40bbf2a-3afc-5c4b-bbf2-e36d48870b57","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-smit1-low-pool","predicate":"loss_decreases","statement":"The original report described profound brain myo-inositol deficiency in its lethal mouse transport-loss model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"44235ac8-c141-5008-b978-122f0a287965","mechanism_event_label":"Loss of a transport route caused a major free-inositol deficit in this reported model.","subject":{"id":"7ee41a04-bc5c-53e9-a798-16c5214d8854","slug":"mouse-slc5a3","display_name":"Mouse Slc5a3 (SMIT1)","entity_type_key":"protein"},"object":{"id":"48dc495b-33ba-5963-947d-c7bcf7f574a3","slug":"brain-myo-inositol","display_name":"Brain myo-inositol pool","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"44235ac8-c141-5008-b978-122f0a287965","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-smit1-low-pool-event","event_type":"biochemical_relationship","label":"Loss of a transport route caused a major free-inositol deficit in this reported model.","description":"The original report described profound brain myo-inositol deficiency in its lethal mouse transport-loss model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7ee41a04-bc5c-53e9-a798-16c5214d8854","slug":"mouse-slc5a3","display_name":"Mouse Slc5a3 (SMIT1)","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"48dc495b-33ba-5963-947d-c7bcf7f574a3","slug":"brain-myo-inositol","display_name":"Brain myo-inositol pool","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/15110328.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee\", \"start_char\": 0, \"end_char\": 1202, \"text_sha256\": \"efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transporter knockout and brain chemical analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"SMIT1-null mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Severe genetic transport failure is not dietary deficiency. Unchanged total PI does not rule out local phosphoinositide abnormalities. An indexed erratum exists (10.1016/j.ymgme.2004.06.012); its content was not retrievable during this curation, so these findings remain provisional reports from the indexed original abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Loss of a transport route caused a major free-inositol deficit in this reported model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"0a320735-30bb-5d3f-ba2b-779e706b2c70","evidence_kind":"source_excerpt","locator":"Lines 431-442","start_line":431,"end_line":442,"excerpt":"### ino-smit1-low-pool\nThe original report described profound brain myo-inositol deficiency in its lethal mouse transport-loss model.\nCondition category: machinery_impairment\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Loss of a transport route caused a major free-inositol deficit in this reported model.\norganism: Mus musculus\ntissue_or_cell_type: Brain\nexperimental_model: Transporter knockout and brain chemical analysis\nlimitations: Severe genetic transport failure is not dietary deficiency. Unchanged total PI does not rule out local phosphoinositide abnormalities. An indexed erratum exists (10.1016/j.ymgme.2004.06.012); its content was not retrievable during this curation, so these findings remain provisional reports from the indexed original abstract.\nexposure: SMIT1-null mice\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/15110328.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee\", \"start_char\": 0, \"end_char\": 1202, \"text_sha256\": \"efa2c78237254c73512bf946f2600f4ead3f1e510cda84a06327906d4663d3ee\"}\n[ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002","model_system":"Transporter knockout and brain chemical analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p15110328] Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. (2004). https://pubmed.ncbi.nlm.nih.gov/15110328/ DOI: 10.1016/j.ymgme.2004.02.002","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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