Component

Mouse ZIP10 / Slc39a10

Mouse ZIP10 / Slc39a10; model and exposure are recorded in linked claims.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Mature-B-cell ZIP10 loss attenuated both T-cell-dependent and T-cell-independent antibody responses; receptor-triggered B-cell proliferation was poor.

    Mouse mature-B-cell ZIP10 loss → B-cell antibody response source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    Mouse ZIP10 / Slc39a10 (affected_transporter)
    evidence_span
    {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"}
    experimental_model
    Mature-B-cell Zip10-deficient mice
    exposure
    B-cell ZIP10 loss versus controls and receptor-activation comparisons.
    limitations
    Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mus musculus
    plain_language
    The signaling defect impaired the measured antibody responses.
    primary_references
    [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
    tissue_or_cell_type
    B cells and antibody responses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1111–1123

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mature-B-cell Zip10-deficient mice · source_derived_draft · unverified_draft

    ### zn-sig-zip10-antibody Mature-B-cell ZIP10 loss attenuated both T-cell-dependent and T-cell-independent antibody responses; receptor-triggered B-cell proliferation was poor. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: The signaling defect impaired the measured antibody responses. organism: Mus musculus tissue_or_cell_type: B cells and antibody responses experimental_model: Mature-B-cell Zip10-deficient mice limitations: Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases. exposure: B-cell ZIP10 loss versus controls and receptor-activation comparisons. cross_nutrient: Mouse ZIP10 / Slc39a10 (affected_transporter) evidence_span: {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"} [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
    Complete structured claim and evidence

  2. ZIP10 loss in mature mouse B cells reduced CD45R phosphatase activity.

    Mouse mature-B-cell ZIP10 loss → B-cell CD45R phosphatase activity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    Mouse ZIP10 / Slc39a10 (affected_transporter); Mouse CD45R / Ptprc B-cell isoform (affected_phosphatase)
    evidence_span
    {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"}
    experimental_model
    Mature-B-cell Zip10-deficient mice
    exposure
    B-cell ZIP10 loss versus controls and receptor-activation comparisons.
    limitations
    Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mus musculus
    plain_language
    A zinc transporter supported the phosphatase that helps tune B-cell signaling.
    primary_references
    [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
    tissue_or_cell_type
    B cells and antibody responses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1083–1095

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mature-B-cell Zip10-deficient mice · source_derived_draft · unverified_draft

    ### zn-sig-zip10-cd45r ZIP10 loss in mature mouse B cells reduced CD45R phosphatase activity. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A zinc transporter supported the phosphatase that helps tune B-cell signaling. organism: Mus musculus tissue_or_cell_type: B cells and antibody responses experimental_model: Mature-B-cell Zip10-deficient mice limitations: Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases. exposure: B-cell ZIP10 loss versus controls and receptor-activation comparisons. cross_nutrient: Mouse ZIP10 / Slc39a10 (affected_transporter); Mouse CD45R / Ptprc B-cell isoform (affected_phosphatase) evidence_span: {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"} [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
    Complete structured claim and evidence

  3. Reduced CD45R activity in ZIP10-deficient B cells was linked to LYN hyperactivation and dysregulated receptor signaling.

    Mouse mature-B-cell ZIP10 loss → B-cell LYN activation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    Mouse ZIP10 / Slc39a10 (affected_transporter); Mouse CD45R / Ptprc B-cell isoform (upstream_phosphatase); Mouse LYN kinase (affected_kinase)
    evidence_span
    {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"}
    experimental_model
    Mature-B-cell Zip10-deficient mice
    exposure
    B-cell ZIP10 loss versus controls and receptor-activation comparisons.
    limitations
    Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Mus musculus
    plain_language
    Losing the transporter caused excessive activity at one signaling step rather than simply turning everything down.
    primary_references
    [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
    tissue_or_cell_type
    B cells and antibody responses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1097–1109

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mature-B-cell Zip10-deficient mice · source_derived_draft · unverified_draft

    ### zn-sig-zip10-lyn Reduced CD45R activity in ZIP10-deficient B cells was linked to LYN hyperactivation and dysregulated receptor signaling. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Losing the transporter caused excessive activity at one signaling step rather than simply turning everything down. organism: Mus musculus tissue_or_cell_type: B cells and antibody responses experimental_model: Mature-B-cell Zip10-deficient mice limitations: Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases. exposure: B-cell ZIP10 loss versus controls and receptor-activation comparisons. cross_nutrient: Mouse ZIP10 / Slc39a10 (affected_transporter); Mouse CD45R / Ptprc B-cell isoform (upstream_phosphatase); Mouse LYN kinase (affected_kinase) evidence_span: {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"} [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards