{"id":"f8048ad8-9e7c-5772-af31-253378ca0f71","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-zip10-antibody","predicate":"attenuated","statement":"Mature-B-cell ZIP10 loss attenuated both T-cell-dependent and T-cell-independent antibody responses; receptor-triggered B-cell proliferation was poor.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4078bd25-6b7b-51c1-ae6a-61294e6c6d88","mechanism_event_label":"The signaling defect impaired the measured antibody responses.","subject":{"id":"cf3127a4-a16a-5907-96b4-3273fe4fe379","slug":"mouse-b-cell-zip10-loss","display_name":"Mouse mature-B-cell ZIP10 loss","entity_type_key":"cellular_process"},"object":{"id":"fdb64907-9b63-5269-9ca0-fb52e1e16a4a","slug":"b-cell-antibody-response","display_name":"B-cell antibody response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4078bd25-6b7b-51c1-ae6a-61294e6c6d88","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-zip10-antibody-event","event_type":"biochemical_relationship","label":"The signaling defect impaired the measured antibody responses.","description":"Mature-B-cell ZIP10 loss attenuated both T-cell-dependent and T-cell-independent antibody responses; receptor-triggered B-cell proliferation was poor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"95f28e8a-7199-565b-9eda-2c0232cbc9c5","slug":"mouse-slc39a10","display_name":"Mouse ZIP10 / Slc39a10","entity_type_key":"protein"},"role":"affected_transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cf3127a4-a16a-5907-96b4-3273fe4fe379","slug":"mouse-b-cell-zip10-loss","display_name":"Mouse mature-B-cell ZIP10 loss","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fdb64907-9b63-5269-9ca0-fb52e1e16a4a","slug":"b-cell-antibody-response","display_name":"B-cell antibody response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Mouse ZIP10 / Slc39a10 (affected_transporter)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-signaling-sources/25074919-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mature-B-cell Zip10-deficient mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"B-cell ZIP10 loss versus controls and receptor-activation comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The signaling defect impaired the measured antibody responses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"B cells and antibody responses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e887eb6b-475b-5a3d-90b5-2c2a6586478a","evidence_kind":"source_excerpt","locator":"Lines 1111-1123","start_line":1111,"end_line":1123,"excerpt":"### zn-sig-zip10-antibody\nMature-B-cell ZIP10 loss attenuated both T-cell-dependent and T-cell-independent antibody responses; receptor-triggered B-cell proliferation was poor.\nCondition category: machinery_impairment\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The signaling defect impaired the measured antibody responses.\norganism: Mus musculus\ntissue_or_cell_type: B cells and antibody responses\nexperimental_model: Mature-B-cell Zip10-deficient mice\nlimitations: Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases.\nexposure: B-cell ZIP10 loss versus controls and receptor-activation comparisons.\ncross_nutrient: Mouse ZIP10 / Slc39a10 (affected_transporter)\nevidence_span: {\"source_cache\": \"artifacts/zinc-signaling-sources/25074919-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7\"}\n[zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111","model_system":"Mature-B-cell Zip10-deficient mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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