Component
B-cell CD45R phosphatase activity
B-cell CD45R phosphatase activity; model and exposure are recorded in linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
ZIP10 loss in mature mouse B cells reduced CD45R phosphatase activity.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Mouse ZIP10 / Slc39a10 (affected_transporter); Mouse CD45R / Ptprc B-cell isoform (affected_phosphatase)
- evidence_span
- {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"}
- experimental_model
- Mature-B-cell Zip10-deficient mice
- exposure
- B-cell ZIP10 loss versus controls and receptor-activation comparisons.
- limitations
- Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Mus musculus
- plain_language
- A zinc transporter supported the phosphatase that helps tune B-cell signaling.
- primary_references
- [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
- tissue_or_cell_type
- B cells and antibody responses
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1083–1095
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mature-B-cell Zip10-deficient mice · source_derived_draft · unverified_draft
### zn-sig-zip10-cd45r ZIP10 loss in mature mouse B cells reduced CD45R phosphatase activity. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A zinc transporter supported the phosphatase that helps tune B-cell signaling. organism: Mus musculus tissue_or_cell_type: B cells and antibody responses experimental_model: Mature-B-cell Zip10-deficient mice limitations: Genetic loss is distinct from dietary shortage; CD45R/LYN is the study-supported pathway, not a universal direct zinc activation rule for phosphatases. exposure: B-cell ZIP10 loss versus controls and receptor-activation comparisons. cross_nutrient: Mouse ZIP10 / Slc39a10 (affected_transporter); Mouse CD45R / Ptprc B-cell isoform (affected_phosphatase) evidence_span: {"source_cache": "artifacts/zinc-signaling-sources/25074919-abstract.txt", "locator": "Primary indexed abstract", "file_sha256": "d3032e44cfa64a54cd560b24872d88e69db456a150510b6e4cde64a11e18b4b7"} [zn-sig-25074919] Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. (2014). https://pubmed.ncbi.nlm.nih.gov/25074919/ DOI: 10.1073/pnas.1323557111
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.