Component
Mouse carnitine transporter Octn2 / Slc22a5
Mouse carnitine transporter Octn2 / Slc22a5. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mangiferin increased renal Mouse carnitine transporter Octn2 / Slc22a5 expression in the hyperuricemic mice.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/21348301.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58", "start_char": 0, "end_char": 1981, "text_sha256": "7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58"}
- experimental_model
- Seven-day potassium-oxonate hyperuricemia model
- exposure
- Mangiferin 50, 100 or 200 mg/kg orally
- limitations
- Animal expression findings; no human carnitine-retention or gout-treatment conclusion.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Mus musculus
- plain_language
- A transporter linked to carnitine also responded.
- primary_references
- [mangiferin-p21348301] [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice]. (2010). https://pubmed.ncbi.nlm.nih.gov/21348301/
- tissue_or_cell_type
- Kidney
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1004–1015
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven-day potassium-oxonate hyperuricemia model · source_derived_draft · unverified_draft
### mangiferin-mouse-slc22a5 Mangiferin increased renal Mouse carnitine transporter Octn2 / Slc22a5 expression in the hyperuricemic mice. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter linked to carnitine also responded. organism: Mus musculus tissue_or_cell_type: Kidney experimental_model: Seven-day potassium-oxonate hyperuricemia model limitations: Animal expression findings; no human carnitine-retention or gout-treatment conclusion. exposure: Mangiferin 50, 100 or 200 mg/kg orally evidence_span: {"source_cache": "artifacts/mangiferin-research/21348301.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58", "start_char": 0, "end_char": 1981, "text_sha256": "7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58"} [mangiferin-p21348301] [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice]. (2010). https://pubmed.ncbi.nlm.nih.gov/21348301/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.