{"id":"bba7f715-804b-5dc6-ae9e-2a958471f8a5","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-mouse-slc22a5","predicate":"increases_expression","statement":"Mangiferin increased renal Mouse carnitine transporter Octn2 / Slc22a5 expression in the hyperuricemic mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5e5b0f47-70f9-59c8-b8df-5c6b92ee67b9","mechanism_event_label":"A transporter linked to carnitine also responded.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"cb4d15e3-bce8-519d-baab-4c3b06931f28","slug":"mouse-slc22a5","display_name":"Mouse carnitine transporter Octn2 / Slc22a5","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"5e5b0f47-70f9-59c8-b8df-5c6b92ee67b9","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-mouse-slc22a5-event","event_type":"biochemical_relationship","label":"A transporter linked to carnitine also responded.","description":"Mangiferin increased renal Mouse carnitine transporter Octn2 / Slc22a5 expression in the hyperuricemic mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"known_transporter_substrate_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"cb4d15e3-bce8-519d-baab-4c3b06931f28","slug":"mouse-slc22a5","display_name":"Mouse carnitine transporter Octn2 / Slc22a5","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/21348301.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58\", \"start_char\": 0, \"end_char\": 1981, \"text_sha256\": \"7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Seven-day potassium-oxonate hyperuricemia model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin 50, 100 or 200 mg/kg orally","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal expression findings; no human carnitine-retention or gout-treatment conclusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A transporter linked to carnitine also responded.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p21348301] [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice]. (2010). https://pubmed.ncbi.nlm.nih.gov/21348301/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"313edb97-3822-5aa5-a2a0-72fbd7355f83","evidence_kind":"source_excerpt","locator":"Lines 1004-1015","start_line":1004,"end_line":1015,"excerpt":"### mangiferin-mouse-slc22a5\nMangiferin increased renal Mouse carnitine transporter Octn2 / Slc22a5 expression in the hyperuricemic mice.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A transporter linked to carnitine also responded.\norganism: Mus musculus\ntissue_or_cell_type: Kidney\nexperimental_model: Seven-day potassium-oxonate hyperuricemia model\nlimitations: Animal expression findings; no human carnitine-retention or gout-treatment conclusion.\nexposure: Mangiferin 50, 100 or 200 mg/kg orally\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/21348301.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58\", \"start_char\": 0, \"end_char\": 1981, \"text_sha256\": \"7c27a677db4a27cc088cfd83ce3506ffdfd866ef91250732b1dd2287d4cf4b58\"}\n[mangiferin-p21348301] [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice]. 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