Component

Mouse vesicular glutamate transporter 2 / Slc17a6

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Deleting Slc17a6 selectively in mouse dopamine neurons abolished their cultured glutamate release and greatly reduced excitatory output in mesoaccumbens slices.

    Mouse vesicular glutamate transporter 2 / Slc17a6 → Glutamate release from mouse dopamine neurons source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse dopamine-neuron conditional knockout, culture and brain slices.
    limitations
    Cell-specific deletion is not global glutamate deficiency.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    A dopamine neuron can require separate machinery to release glutamate too.
    primary_references
    Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20223200/ · DOI 10.1016/j.neuron.2010.02.012
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 306–312

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse dopamine-neuron conditional knockout, culture and brain slices. · source_derived_draft · unverified_draft

    ## glutamate-vglut2-dopamine-neuron-release A dopamine neuron can require separate machinery to release glutamate too. Deleting Slc17a6 selectively in mouse dopamine neurons abolished their cultured glutamate release and greatly reduced excitatory output in mesoaccumbens slices. Model: Mouse dopamine-neuron conditional knockout, culture and brain slices. Limitations: Cell-specific deletion is not global glutamate deficiency. Evidence access: Primary full text Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20223200/ · DOI 10.1016/j.neuron.2010.02.012
    Complete structured claim and evidence

  2. Dopamine-neuron Slc17a6 deletion reduced dopamine stores in ventral-striatal projections and reduced cocaine-stimulated locomotor responses while sparing baseline motor behavior.

    Mouse vesicular glutamate transporter 2 / Slc17a6 → Mouse ventral-striatal dopamine stores source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse conditional knockout with tissue dopamine and behavioral measurements.
    limitations
    Multiple downstream effects coexist; this does not prove every dopamine neuron or behavior depends equally on VGLUT2.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    Removing the glutamate-loading route changed another transmitter system in a specific circuit.
    primary_references
    Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20223200/ · DOI 10.1016/j.neuron.2010.02.012
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 322–328

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse conditional knockout with tissue dopamine and behavioral measurements. · source_derived_draft · unverified_draft

    ## glutamate-vglut2-dopamine-stores Removing the glutamate-loading route changed another transmitter system in a specific circuit. Dopamine-neuron Slc17a6 deletion reduced dopamine stores in ventral-striatal projections and reduced cocaine-stimulated locomotor responses while sparing baseline motor behavior. Model: Mouse conditional knockout with tissue dopamine and behavioral measurements. Limitations: Multiple downstream effects coexist; this does not prove every dopamine neuron or behavior depends equally on VGLUT2. Evidence access: Primary full text Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20223200/ · DOI 10.1016/j.neuron.2010.02.012
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards