{"id":"0acbb5fe-77a8-5bdf-9e67-7bb1b127f204","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-vglut2-dopamine-stores","predicate":"supports_tested","statement":"Dopamine-neuron Slc17a6 deletion reduced dopamine stores in ventral-striatal projections and reduced cocaine-stimulated locomotor responses while sparing baseline motor behavior.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1749e32f-3dad-5194-8b91-b6ca36731dcd","mechanism_event_label":"Removing the glutamate-loading route changed another transmitter system in a specific circuit.","subject":{"id":"485641b1-c255-547f-bbd7-7f8c37c9492a","slug":"mouse-slc17a6","display_name":"Mouse vesicular glutamate transporter 2 / Slc17a6","entity_type_key":"protein"},"object":{"id":"d38122f9-5aee-507b-8f14-9b9fc41164ab","slug":"mouse-ventral-striatal-dopamine-stores","display_name":"Mouse ventral-striatal dopamine stores","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1749e32f-3dad-5194-8b91-b6ca36731dcd","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-vglut2-dopamine-stores-event","event_type":"observed_relationship","label":"Removing the glutamate-loading route changed another transmitter system in a specific circuit.","description":"Dopamine-neuron Slc17a6 deletion reduced dopamine stores in ventral-striatal projections and reduced cocaine-stimulated locomotor responses while sparing baseline motor behavior.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"485641b1-c255-547f-bbd7-7f8c37c9492a","slug":"mouse-slc17a6","display_name":"Mouse vesicular glutamate transporter 2 / Slc17a6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d38122f9-5aee-507b-8f14-9b9fc41164ab","slug":"mouse-ventral-striatal-dopamine-stores","display_name":"Mouse ventral-striatal dopamine stores","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9cca6209-0603-5ab7-96ad-2f3ae4b772d2","slug":"dopamine","display_name":"Dopamine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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