{"id":"c0f611a2-10bb-5636-9985-0d15c4e7f6ba","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-vglut2-dopamine-neuron-release","predicate":"enables","statement":"Deleting Slc17a6 selectively in mouse dopamine neurons abolished their cultured glutamate release and greatly reduced excitatory output in mesoaccumbens slices.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4b4459d4-55ab-5cad-88d5-37d74df77277","mechanism_event_label":"A dopamine neuron can require separate machinery to release glutamate too.","subject":{"id":"485641b1-c255-547f-bbd7-7f8c37c9492a","slug":"mouse-slc17a6","display_name":"Mouse vesicular glutamate transporter 2 / Slc17a6","entity_type_key":"protein"},"object":{"id":"989a85e5-b872-5abd-bea7-3df2af54bdae","slug":"mouse-dopamine-neuron-glutamate-release","display_name":"Glutamate release from mouse dopamine neurons","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4b4459d4-55ab-5cad-88d5-37d74df77277","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-vglut2-dopamine-neuron-release-event","event_type":"observed_relationship","label":"A dopamine neuron can require separate machinery to release glutamate too.","description":"Deleting Slc17a6 selectively in mouse dopamine neurons abolished their cultured glutamate release and greatly reduced excitatory output in mesoaccumbens slices.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"485641b1-c255-547f-bbd7-7f8c37c9492a","slug":"mouse-slc17a6","display_name":"Mouse vesicular glutamate transporter 2 / Slc17a6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"989a85e5-b872-5abd-bea7-3df2af54bdae","slug":"mouse-dopamine-neuron-glutamate-release","display_name":"Glutamate release from mouse dopamine neurons","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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