Component

Mouse proline dehydrogenase / Prodh

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Pharmacological inhibition of Prodh impaired lung-metastasis formation in orthotopic 4T1 and EMT6.5 mouse breast-cancer models.

    Mouse proline dehydrogenase / Prodh → Lung-metastasis formation in mouse breast-cancer models source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse breast-cancer models, complemented by three-dimensional culture and human tumor-expression comparisons.
    limitations
    This does not establish that dietary proline causes metastasis or that proline restriction is a proven treatment.
    nutrient_topic
    L-Proline collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Proline
    plain_language
    A proline-consuming pathway can support growth in a metastatic setting.
    primary_references
    Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28492237/ · DOI 10.1038/ncomms15267

    L-Proline: synthesis, collagen processing, redox metabolism and cross-nutrient mechanisms (2026-09-19) · lines 382–388

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse breast-cancer models, complemented by three-dimensional culture and human tumor-expression comparisons. · source_derived_draft · unverified_draft

    ## l-proline-mouse-metastatic-catabolism A proline-consuming pathway can support growth in a metastatic setting. Pharmacological inhibition of Prodh impaired lung-metastasis formation in orthotopic 4T1 and EMT6.5 mouse breast-cancer models. Model: Mouse breast-cancer models, complemented by three-dimensional culture and human tumor-expression comparisons. Limitations: This does not establish that dietary proline causes metastasis or that proline restriction is a proven treatment. Evidence access: Primary abstract Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28492237/ · DOI 10.1038/ncomms15267
    Complete structured claim and evidence

  2. Prodh loss blocked proline nitrogen utilization by mouse RPE and diminished delivery of proline-derived amino-acid nitrogen to the retina.

    Mouse proline dehydrogenase / Prodh → Mouse RPE-to-retina transfer of proline-derived amino-acid nitrogen source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary final published full text
    experimental_model
    Mouse Prodh mutant tissue and isotope-transfer experiments, supported by coculture and in-vivo tracing.
    limitations
    Mouse compartmental transfer is not proof that oral proline prevents human retinal degeneration.
    nutrient_topic
    L-Proline collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Proline
    plain_language
    The retina depends on processing in a neighboring support tissue.
    primary_references
    Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37741457/ · DOI 10.1016/j.jbc.2023.105275
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Proline: synthesis, collagen processing, redox metabolism and cross-nutrient mechanisms (2026-09-19) · lines 334–340

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse Prodh mutant tissue and isotope-transfer experiments, supported by coculture and in-vivo tracing. · source_derived_draft · unverified_draft

    ## l-proline-rpe-retina-nitrogen The retina depends on processing in a neighboring support tissue. Prodh loss blocked proline nitrogen utilization by mouse RPE and diminished delivery of proline-derived amino-acid nitrogen to the retina. Model: Mouse Prodh mutant tissue and isotope-transfer experiments, supported by coculture and in-vivo tracing. Limitations: Mouse compartmental transfer is not proof that oral proline prevents human retinal degeneration. Evidence access: Primary final published full text Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37741457/ · DOI 10.1016/j.jbc.2023.105275
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards