{"id":"1c056ccf-4c8c-5225-ae04-19631c0b425a","stable_key":"6612c190-1948-5bcf-bbe3-a7f6c50fa3cf:l-proline-rpe-retina-nitrogen","predicate":"enables","statement":"Prodh loss blocked proline nitrogen utilization by mouse RPE and diminished delivery of proline-derived amino-acid nitrogen to the retina.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b0bedabc-941c-5e6b-afae-4acefe9a241e","mechanism_event_label":"The retina depends on processing in a neighboring support tissue.","subject":{"id":"3c8f99f8-4ce4-5355-ac90-9c371bf0257e","slug":"mouse-prodh","display_name":"Mouse proline dehydrogenase / Prodh","entity_type_key":"protein"},"object":{"id":"ec7b66c9-aa20-5902-938c-8267b62ab893","slug":"mouse-rpe-retina-proline-nitrogen-transfer","display_name":"Mouse RPE-to-retina transfer of proline-derived amino-acid nitrogen","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b0bedabc-941c-5e6b-afae-4acefe9a241e","stable_key":"6612c190-1948-5bcf-bbe3-a7f6c50fa3cf:l-proline-rpe-retina-nitrogen-event","event_type":"observed_relationship","label":"The retina depends on processing in a neighboring support tissue.","description":"Prodh loss blocked proline nitrogen utilization by mouse RPE and diminished delivery of proline-derived amino-acid nitrogen to the retina.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3c8f99f8-4ce4-5355-ac90-9c371bf0257e","slug":"mouse-prodh","display_name":"Mouse proline dehydrogenase / Prodh","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ec7b66c9-aa20-5902-938c-8267b62ab893","slug":"mouse-rpe-retina-proline-nitrogen-transfer","display_name":"Mouse RPE-to-retina transfer of proline-derived amino-acid nitrogen","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"70ccd53c-83ad-5251-a4f5-6370973bc40a","slug":"l-proline","display_name":"L-Proline","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"8637bb39-2c30-5168-baaf-3e613d831db0","slug":"glutamine","display_name":"L-Glutamine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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