Component
Experimental mouse Nherf1 knockout
Experimental mouse Nherf1 knockout. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Apical PTH-receptor stimulation of PLC was impaired in Nherf1-deficient mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/16987995.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc", "start_char": 0, "end_char": 1699, "text_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc"}
- experimental_model
- Receptor-fragment stimulation, knockout and signaling-bypass experiments
- exposure
- PTH-(1–34), apically selective PTH-(3–34), PKC/PKA pathway stimulation
- limitations
- Apical and basolateral receptor routes differ. Loss of one scaffold does not eliminate every PTH response.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Mouse
- plain_language
- The receptor needed its local signaling scaffold for this route.
- primary_references
- [phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. (2007). https://pubmed.ncbi.nlm.nih.gov/16987995/ DOI: 10.1152/ajpcell.00126.2006
- tissue_or_cell_type
- Renal proximal tubule brush-border membrane
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 412–423
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor-fragment stimulation, knockout and signaling-bypass experiments · source_derived_draft · unverified_draft
### phosphorus-nherf-plc Apical PTH-receptor stimulation of PLC was impaired in Nherf1-deficient mice. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor needed its local signaling scaffold for this route. organism: Mouse tissue_or_cell_type: Renal proximal tubule brush-border membrane experimental_model: Receptor-fragment stimulation, knockout and signaling-bypass experiments limitations: Apical and basolateral receptor routes differ. Loss of one scaffold does not eliminate every PTH response. exposure: PTH-(1–34), apically selective PTH-(3–34), PKC/PKA pathway stimulation evidence_span: {"source_cache": "artifacts/phosphorus-research/16987995.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc", "start_char": 0, "end_char": 1699, "text_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc"} [phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. (2007). https://pubmed.ncbi.nlm.nih.gov/16987995/ DOI: 10.1152/ajpcell.00126.2006
Complete structured claim and evidence
Where it participates (unsigned role)
PTH-(3–34), used to stimulate apical receptors, failed to induce NaPi-IIa internalization in Nherf1-deficient mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/16987995.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc", "start_char": 0, "end_char": 1699, "text_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc"}
- experimental_model
- Receptor-fragment stimulation, knockout and signaling-bypass experiments
- exposure
- PTH-(1–34), apically selective PTH-(3–34), PKC/PKA pathway stimulation
- limitations
- Apical and basolateral receptor routes differ. Loss of one scaffold does not eliminate every PTH response.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Mouse
- plain_language
- The isolated apical route failed, unlike the broader PTH-(1–34) stimulation.
- primary_references
- [phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. (2007). https://pubmed.ncbi.nlm.nih.gov/16987995/ DOI: 10.1152/ajpcell.00126.2006
- tissue_or_cell_type
- Renal proximal tubule brush-border membrane
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 425–436
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor-fragment stimulation, knockout and signaling-bypass experiments · source_derived_draft · unverified_draft
### phosphorus-nherf-napi PTH-(3–34), used to stimulate apical receptors, failed to induce NaPi-IIa internalization in Nherf1-deficient mice. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The isolated apical route failed, unlike the broader PTH-(1–34) stimulation. organism: Mouse tissue_or_cell_type: Renal proximal tubule brush-border membrane experimental_model: Receptor-fragment stimulation, knockout and signaling-bypass experiments limitations: Apical and basolateral receptor routes differ. Loss of one scaffold does not eliminate every PTH response. exposure: PTH-(1–34), apically selective PTH-(3–34), PKC/PKA pathway stimulation evidence_span: {"source_cache": "artifacts/phosphorus-research/16987995.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc", "start_char": 0, "end_char": 1699, "text_sha256": "c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc"} [phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. (2007). https://pubmed.ncbi.nlm.nih.gov/16987995/ DOI: 10.1152/ajpcell.00126.2006
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.