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Loss of one scaffold does not eliminate every PTH response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The receptor needed its local signaling scaffold for this route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 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Loss of one scaffold does not eliminate every PTH response.\nexposure: PTH-(1–34), apically selective PTH-(3–34), PKC/PKA pathway stimulation\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/16987995.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc\", \"start_char\": 0, \"end_char\": 1699, \"text_sha256\": \"c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc\"}\n[phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 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