Component

Experimental mouse Mfsd2a-null genotype

Experimental mouse Mfsd2a-null genotype. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Mfsd2a-null mice had markedly reduced brain DHA abundance.

    Experimental mouse Mfsd2a-null genotype → Mouse brain DHA abundance source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"}
    experimental_model
    Mouse knockout and cell transport experiments
    exposure
    LPC-bound versus unesterified DHA; sodium-dependent transport
    limitations
    LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA.
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Mouse Mfsd2a and experimental expression system
    plain_language
    The tissue fatty-acid pool changed downstream of the transport defect.
    primary_references
    [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
    tissue_or_cell_type
    Blood-brain-barrier endothelium
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 984–995

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse knockout and cell transport experiments · source_derived_draft · unverified_draft

    ### choline-mfsd2a-dha Mfsd2a-null mice had markedly reduced brain DHA abundance. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tissue fatty-acid pool changed downstream of the transport defect. organism: Mouse Mfsd2a and experimental expression system tissue_or_cell_type: Blood-brain-barrier endothelium experimental_model: Mouse knockout and cell transport experiments limitations: LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA. exposure: LPC-bound versus unesterified DHA; sodium-dependent transport evidence_span: {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"} [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
    Complete structured claim and evidence

  2. Mfsd2a-null mice had markedly reduced uptake of plasma-labeled LPC-DHA into the brain.

    Experimental mouse Mfsd2a-null genotype → Mouse plasma-to-brain LPC-DHA uptake source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"}
    experimental_model
    Mouse knockout and cell transport experiments
    exposure
    LPC-bound versus unesterified DHA; sodium-dependent transport
    limitations
    LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA.
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Mouse Mfsd2a and experimental expression system
    plain_language
    Less of the carrier lipid reached the brain.
    primary_references
    [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
    tissue_or_cell_type
    Blood-brain-barrier endothelium
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 971–982

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse knockout and cell transport experiments · source_derived_draft · unverified_draft

    ### choline-mfsd2a-uptake Mfsd2a-null mice had markedly reduced uptake of plasma-labeled LPC-DHA into the brain. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less of the carrier lipid reached the brain. organism: Mouse Mfsd2a and experimental expression system tissue_or_cell_type: Blood-brain-barrier endothelium experimental_model: Mouse knockout and cell transport experiments limitations: LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA. exposure: LPC-bound versus unesterified DHA; sodium-dependent transport evidence_span: {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"} [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards