Component
Mouse plasma-to-brain LPC-DHA uptake
Mouse plasma-to-brain LPC-DHA uptake. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mfsd2a-null mice had markedly reduced uptake of plasma-labeled LPC-DHA into the brain.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"}
- experimental_model
- Mouse knockout and cell transport experiments
- exposure
- LPC-bound versus unesterified DHA; sodium-dependent transport
- limitations
- LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mouse Mfsd2a and experimental expression system
- plain_language
- Less of the carrier lipid reached the brain.
- primary_references
- [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
- tissue_or_cell_type
- Blood-brain-barrier endothelium
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 971–982
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse knockout and cell transport experiments · source_derived_draft · unverified_draft
### choline-mfsd2a-uptake Mfsd2a-null mice had markedly reduced uptake of plasma-labeled LPC-DHA into the brain. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less of the carrier lipid reached the brain. organism: Mouse Mfsd2a and experimental expression system tissue_or_cell_type: Blood-brain-barrier endothelium experimental_model: Mouse knockout and cell transport experiments limitations: LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA. exposure: LPC-bound versus unesterified DHA; sodium-dependent transport evidence_span: {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"} [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.