Component
Glutathione-dependent IL-1beta transcription in mouse macrophages
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Serine-derived glycine supported glutathione synthesis required for optimal LPS-induced IL-1beta mRNA expression; inflammasome activation was not the affected step.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse macrophage metabolic manipulation and LPS stimulation.
- limitations
- IL-1beta transcription and inflammasome-mediated processing are different endpoints.
- nutrient_topic
- L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Serine
- plain_language
- An antioxidant-building pathway can support inflammatory gene expression.
- primary_references
- Serine Metabolism Supports Macrophage IL-1β Production. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30773464/ · DOI 10.1016/j.cmet.2019.01.014
L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19) · lines 230–236
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse macrophage metabolic manipulation and LPS stimulation. · source_derived_draft · unverified_draft
## l-serine-macrophage-gsh An antioxidant-building pathway can support inflammatory gene expression. Serine-derived glycine supported glutathione synthesis required for optimal LPS-induced IL-1beta mRNA expression; inflammasome activation was not the affected step. Model: Mouse macrophage metabolic manipulation and LPS stimulation. Limitations: IL-1beta transcription and inflammasome-mediated processing are different endpoints. Evidence access: Primary abstract Serine Metabolism Supports Macrophage IL-1β Production. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30773464/ · DOI 10.1016/j.cmet.2019.01.014
Complete structured claim and evidenceCell-permeable glutathione, but not formate, rescued IL-1beta mRNA expression under serine restriction in the macrophage experiments.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Macrophage culture with serine restriction and metabolite add-back.
- limitations
- The delivered compound was cell-permeable GSH, not an assumed effect of oral glutathione.
- nutrient_topic
- L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Serine
- plain_language
- The limiting branch differs from the nucleotide requirement in dividing T cells.
- primary_references
- Serine Metabolism Supports Macrophage IL-1β Production. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30773464/ · DOI 10.1016/j.cmet.2019.01.014
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19) · lines 238–244
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Macrophage culture with serine restriction and metabolite add-back. · source_derived_draft · unverified_draft
## l-serine-macrophage-rescue The limiting branch differs from the nucleotide requirement in dividing T cells. Cell-permeable glutathione, but not formate, rescued IL-1beta mRNA expression under serine restriction in the macrophage experiments. Model: Macrophage culture with serine restriction and metabolite add-back. Limitations: The delivered compound was cell-permeable GSH, not an assumed effect of oral glutathione. Evidence access: Primary abstract Serine Metabolism Supports Macrophage IL-1β Production. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30773464/ · DOI 10.1016/j.cmet.2019.01.014
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.