{"id":"e03661f3-b839-58e9-99e6-78ea3d9a9533","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-macrophage-rescue","predicate":"rescues","statement":"Cell-permeable glutathione, but not formate, rescued IL-1beta mRNA expression under serine restriction in the macrophage experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"49150e1e-3e93-54e0-9763-f34ecc572d10","mechanism_event_label":"The limiting branch differs from the nucleotide requirement in dividing T cells.","subject":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"object":{"id":"142ac8f2-c0bc-58a6-945f-0d62dcc14973","slug":"mouse-macrophage-gsh-il1b","display_name":"Glutathione-dependent IL-1beta transcription in mouse macrophages","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"49150e1e-3e93-54e0-9763-f34ecc572d10","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-macrophage-rescue-event","event_type":"observed_relationship","label":"The limiting branch differs from the nucleotide requirement in dividing T cells.","description":"Cell-permeable glutathione, but not formate, rescued IL-1beta mRNA expression under serine restriction in the macrophage experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"142ac8f2-c0bc-58a6-945f-0d62dcc14973","slug":"mouse-macrophage-gsh-il1b","display_name":"Glutathione-dependent IL-1beta transcription in mouse macrophages","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Macrophage culture with serine restriction and metabolite add-back.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The delivered compound was cell-permeable GSH, not an assumed effect of oral glutathione.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The limiting branch differs from the nucleotide requirement in dividing T cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Serine Metabolism Supports Macrophage IL-1β Production. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30773464/ · DOI 10.1016/j.cmet.2019.01.014","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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