Mouse histamine-producing neurons: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Histamine-neuron ablation or acute chemogenetic inhibition shortened, but did not abolish, modafinil-induced wakefulness in mice.
Mouse histamine-producing neurons → Mouse wake duration Recorded from sourceungraded
Experimental context and source evidence
evidence_access
Full XML obtained; relevant results/methods inspected. Not exhaustive reanalysis of figures or data.
experimental_condition
Modafinil with intact neurons ablated or inhibited · Mouse histamine-producing neurons Condition belongs to the full experimental contrast; do not separate a joint intervention.
experimental_condition
Modafinil with intact neurons drug challenge · Modafinil Condition belongs to the full experimental contrast; do not separate a joint intervention.
experimental_contrast
{"intervention": "Histamine-neuron ablation/inhibition plus modafinil", "comparator": "Modafinil with intact neurons", "endpoint": "Histamine-neuron ablation or acute chemogenetic inhibition shortened, but did not abolish, modafinil-induced wakefulness in mice.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "mouse-histamine-neurons", "state": "ablated or inhibited"}, {"entity_slug": "modafinil", "state": "drug challenge"}]} Explicit extracted experimental comparison; source-derived draft.
experimental_model
Mouse genetic and chemogenetic experiments; cell dependency not direct drug binding.
interpretation_status
Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
limitations
Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
plain_language
Histamine-neuron ablation or acute chemogenetic inhibition shortened, but did not abolish, modafinil-induced wakefulness in mice.
primary_references
Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. | 2019 | DOI 10.1093/sleep/zsz031 | PMID 30722053 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/
source_locator
Reviewed reference lines 79-79; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 79–79
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Mouse genetic and chemogenetic experiments; cell dependency not direct drug binding. · Recorded from source · Recorded from source
Genetic removal or acute chemogenetic inhibition of histamine neurons shortened modafinil-induced waking in mice rather than abolishing it. Histamine-neuron activity therefore contributes to sustained wakefulness in that setting, without being established as the direct drug target. Recovery sleep still showed increased NREM delta power, including after histamine-neuron ablation: a homeostatic response persisted. [Histamine-neuron study, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/)
Complete structured claim and evidence

Where it participates (unsigned role)

Recovery sleep showed increased NREM delta power after modafinil, including after histamine-neuron ablation; prolonged waking did not remove this homeostatic response.
Modafinil → Mouse recovery-sleep NREM delta power Recorded from sourceungraded
Experimental context and source evidence
evidence_access
Full XML obtained; relevant results/methods inspected. Not exhaustive reanalysis of figures or data.
experimental_contrast
{"intervention": "Post-modafinil recovery sleep", "comparator": "Study baseline/control", "endpoint": "Recovery sleep showed increased NREM delta power after modafinil, including after histamine-neuron ablation; prolonged waking did not remove this homeostatic response.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
experimental_model
Mouse recovery sleep; intact and histamine-neuron-ablated conditions.
interpretation_status
Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
limitations
Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
plain_language
Recovery sleep showed increased NREM delta power after modafinil, including after histamine-neuron ablation; prolonged waking did not remove this homeostatic response.
primary_references
Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. | 2019 | DOI 10.1093/sleep/zsz031 | PMID 30722053 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/
source_locator
Reviewed reference lines 79-79; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 79–79
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Mouse recovery sleep; intact and histamine-neuron-ablated conditions. · Recorded from source · Recorded from source
Genetic removal or acute chemogenetic inhibition of histamine neurons shortened modafinil-induced waking in mice rather than abolishing it. Histamine-neuron activity therefore contributes to sustained wakefulness in that setting, without being established as the direct drug target. Recovery sleep still showed increased NREM delta power, including after histamine-neuron ablation: a homeostatic response persisted. [Histamine-neuron study, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/)
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Mouse histamine-producing neurons